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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #31: Beta-Cell Biology of Insulin Secretion Part 1 of 5

In pancreatic beta cells, glucose metabolism is essential for the regulation of insulin secretion. Glucose is taken up by glucose transporters and metabolized to generate adenosine triphosphate (ATP), which is the main driver of glucose-induced insulin secretion (GIIS). Increased cytosolic ATP causes closure of ATP-sensitive K+ (KATP) channels, depolarizing the plasma membrane, leading to the opening of voltage-dependent Ca2+ channels (VDCCs), which allows Ca2+ influx. The resultant rise in intracellular Ca2+ concentration ([Ca2+]i) induces exocytosis of insulin granules in the triggering pathway of insulin secretion. In addition, other signals generated by glucose amplify insulin secretion. Lipid metabolism is also involved in GIIS by interacting with glucose metabolism.

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ADA Interview Format

We were at the ADA and AACE and have over 45 video interviews with some great information. Would you prefer to watch a video interview in its entirety, or an interview broken up into Q&A segments? Follow the link and let us know your opinion!

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