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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #30: Insulin Gene Expression and Biosynthesis Part 6 of 6

Regulation of proinsulin conversion: PC2 and PC1/3 are Ca2+-dependent enzyme activities with an acidic pH 5 – 5.5 optimum. Fortunately, the beta granule contains an intraorganellar environment of 1 – 10 mM free Ca2+ and acidic pH 5.5, which ideally suits the requirements for optimal PC2, PC1/3 and CP-H activities within this organelle.

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Question #839

Test Your Knowledge

During the United Kingdom Prospective Diabetes Study (UKPDS), patients with type 2 diabetes were assigned to the intensive treatment arm (received a sulfonylurea or insulin, or metformin if overweight) or a conventional treatment arm (dietary interventions only). In the intensive treatment arm, which one of the following benefits became apparent only when a 10-year follow-up study was conducted? A. Reduced risk of microvascular complications B. Clinically lower overall BMI C. Reduced risk of myocardial infarction D. Lower overall mean A1C Did you get it right? Follow the link to find out!

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