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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #54: Incretin Physiology in Health and Disease Part 4 of 6

Central nervous effects: A role for GLP-1 in the central nervous regulation of food intake has been inferred from the high density of GLP-1 receptors in the hypothalamus. Also, direct intracerebroventricular administration of GLP-1 has caused a significant reduction in food intake in rats, and these actions could be abolished by co-administration of the GLP-1 receptor antagonist exendin.

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