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Dynamics of insulin secretion: Biphasic insulin secretion -- insulin release from pancreatic beta cells in response to glucose is characterized by biphasic kinetics: an initial component (1st phase), which develops rapidly but lasts only a few minutes, followed by a sustained component (2nd phase). It has been thought that the biphasic response of insulin secretion reflects primarily the dynamics of spatially and functionally distinct insulin granules. The prevailing hypothesis is that the 1st phase of insulin secretion is attributable to fusion of predocked granules from a readily releasable pool (RRP) that accounts for less than 5% of total granules, while the 2nd phase involves recruitment of granules from a more distant reserve pool (RP) that accounts for the great majority of total granules.

System shows significant improvement in HbA1c compared to current best therapy available.

With Sanofi's LixiLan® filed for FDA approval, GLP-1 agonist/basal insulin combinations may be potential game changers.

Is high cholesterol associated with risk of type 2, cardiovascular diseases and high mortality rates?

Is weight control possible in pregnant women?

The diabetes drug may have a beneficial effect on neurodegenerative diseases.

For a patient with an A1c of 5.7% who has been on metformin plus diet and exercise for the last 6 months, would you add another diabetes medication to the patient’s treatment? Follow the link to share your opinion.

Based upon a meta-analysis of cardiovascular outcomes in type 2 diabetes studies, findings suggest that a 15% relative risk reduction in nonfatal myocardial infarcts is associated with an A1C reduction of approximately: a) .50% b) 1.0% c) 1.5% d) 2.0% Did you get it right? Follow the link to find out!

Guest Post by David Kliff, Diabetic Investor Recently we learned the identity of the new British Prime Minister, Theresa May, who, according to a post on www.jdrf.org.uk, is a type 1 diabetic. The post states: “The Home Secretary Theresa May is on course to become the first prime minister who …

16-year-old male, type 1 diabetes since 2 years of age, pump therapy. Eats about the same thing daily. Post prandials vary widely. When corrects for highs, gets low.