Resources

Autocrine effect of insulin on insulin secretion: Rodent and human pancreatic beta cells possess the various components of the insulin signaling system, including insulin receptor, insulin-like growth factor-1 (IGF-1) receptor, insulin receptor substrates (IRS-1 and IRS-2), phosphatidylinositol 3-kinase (PI3K), phosphoinositide-dependent kinase-1 (PDK1), and protein kinase B (PKB)/Akt. It has been shown that insulin binds to the insulin receptors on the surface of beta cells and induces phosphorylation of the insulin receptors and IRSs,modulating its own secretion. This effect of insulin is involved especially in the 1st phase of GIIS in mice.

How do consumers and HCPs feel about new technologies and their impact on our health system?

Which of the following is the correct diagnostic cut-point for diabetes? 1) A1C greater than or equal to 7% 2) Fasting plasma glucose (FPG) greater than or equal to 130 mg/dL 3) 2-hour plasma glucose greater than or equal to 200 mg/dL during an oral glucose tolerance test 4) Random plasma glucose greater than or equal to 300mg/dL in a patient with classics symptoms of hyperglycemia or hyperglycemic crisis Did you get it right? Follow the link to find out!

Do you enjoy and ride a bike for exercise? Follow the link to respond!

63-year-old male, moderate cognitive impairment and lives alone. Patient lost a significant amount of weight, frequent symptomatic hypoglycemia, including light-headedness and dizziness, requiring lowering and stopping some of his glucose lowering medications. GLP-1 was stopped and his glucose levels were in normal range. We were very clear that he should not resume his GLP-1 until we saw him again.

In part 2 of this Exclusive Interview, Kimberly Ward explains the integration of the Accu-Check system with an Apple app and how the system's features benefit patients and physicians alike.

In this week's Homerun Slides, the natural history and progression of diabetes.

Gs-protein-coupled receptor: In pancreatic beta cells, various hormones, neurotransmitters, nucleotides, and fatty acids including GLP-1, glucose-dependent insulinotropic polypeptide (GIP), vasoactive intestinal polypeptide (VIP), pituitary adenylate cyclase-activating polypeptide (PACAP), adrenaline, ATP/ADP, lysophosphatidylcholine (LPC), and oleoylethanolamide (OEA) activate their specific receptors. These receptors when coupled with Gs-protein activate adenylate cyclase and increase cAMP production. These cAMP-increasing ligands potentiate both the 1st phase and 2nd phase of GIIS.

Is extreme management of diabetes hurting or helping the kidneys?

Is extreme blood glucose control increasing or decreasing mortality rate in hospitalized patients?