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Insulin resistance is often discussed as though it were one metabolic problem affecting the entire body equally. However, emerging research suggests the picture is more complex. Tissue-specific insulin resistance means that fat, muscle, the liver, and other tissues may not respond to insulin in the same way. More importantly, resistance …

Charcot foot in diabetes can begin with a warning sign that seems almost contradictory: a foot that is hot, red, and swollen but causes surprisingly little pain. For people with diabetic peripheral neuropathy, reduced sensation may hide the severity of the problem. As a result, patients may continue walking on …

The choice of human vs analogue insulin is especially important for people with Type 1 diabetes who live where healthcare resources are limited. Analogue insulins are often preferred because their action can be more predictable and flexible. However, human insulin is generally less expensive and may be easier for health …

A patient develops diabetes in adulthood, so Type 2 diabetes may seem like the obvious diagnosis. However, what if that patient also has chronic pancreatitis, unexplained weight loss, pancreatic surgery, or symptoms of poor nutrient absorption? Those details can change the clinical picture. Careful evaluation can reveal Type 3c diabetes …

Finding the right diabetic neuropathy pain treatment can be challenging when a well-chosen first medication provides only partial relief. Burning, shooting pain, tingling, and allodynia can continue to disrupt sleep, mobility, mood, and daily function. Fortunately, clinicians do not always have to choose between abandoning a partially effective drug and …

Precision diabetes treatment aims to answer a question clinicians and patients face every day: which diabetes drug is most likely to work best for this particular person? A new analysis from the TriMaster crossover trial offers an important clue. Researchers compared several precision-medicine strategies for predicting responses to sitagliptin, canagliflozin, …

Why does eating less sometimes improve insulin sensitivity beyond what we might expect from weight loss alone? Human research points to an intriguing connection between ceramides, insulin resistance, and adiponectin. Findings from the CALERIE research program suggest that sustained, moderate calorie restriction changes circulating bioactive lipids in ways that may …

Does being diagnosed with type 1 diabetes at age 6 carry the same long-term risks as being diagnosed at 16? Researchers have been asking that question for years. Increasingly, evidence suggests that age at type 1 diabetes onset may help explain differences in complication patterns later in life. However, age …

Diabetes prevention remains important long after a pregnancy affected by gestational diabetes. For people who have had gestational diabetes, the years after delivery are an important window for lowering the risk of Type 2 diabetes. Yet healthy choices do not happen in a vacuum. Where someone lives may affect whether …

Continuous glucose monitoring has changed how clinicians and people with diabetes think about glucose control. Yet the next question is more important than whether CGM improves A1C or Time in Range. Can it prevent events that send patients to the emergency department or hospital? Growing evidence suggests that CGM may …