Both medications lowered HbA1c and both groups of patients lost weight…. This randomized, multinational, open-label trial included subjects treated for T2DM with metformin ± sulphonylurea, who had glycated haemoglobin (HbA1c) levels of 7.5–12%. Subjects were assigned to 24 weeks of insulin glargine, titrated to target fasting plasma glucose of 4.0–5.5 mmol/L or liraglutide, escalated …
Read More »Linagliptin/Metformin Combination vs Linagliptin Monotherapy for Type 2 Diabetes
Earlier treatment for poorly controlled type 2 diabetes patients is advocated… Researchers from the University of Calgary, Alberta, Canada, evaluated glucose-lowering treatment strategies with linagliptin and metformin in people with newly diagnosed type 2 diabetes and marked hyperglycemia, a prevalent population for which few dedicated studies of oral antidiabetes drugs …
Read More »Barbara E. Corkey, PhD, Introduction: The Unknown Causes of Diabetes and Obesity
Dr. Barbara E. Corkey introduces herself and explains a little about the work she and her team do in her lab, examining the effects of various substances, both nutritional and non-food substances, on the human cell…. More videos with Dr. Corkey: Introduction: The Unknown Causes of Diabetes and Obesity What …
Read More »Barbara E. Corkey, PhD: Current Strategies to Combat Obesity Not Working
Dr. Barbara E. Corkey, talks about how the current dogma on how our obese patients should lose weight to combat diabetes is simply not working. She notes that we seem to be focusing too much on the wrong things – sending patients home with the advice to lose weight – …
Read More »New Guideline Released on Pharmacological Management of Obesity
The Endocrine Society has released a clinical practice guideline on the pharmacological management of obesity that includes recommendations on strategies for prescribing weight loss drugs.
Read More »Higher Fasting Blood Glucose Linked with Risk of Pancreatic Cancer
For every 0.56 mmol/L increase in fasting blood glucose there was a 14% increase in the rate of pancreatic cancer… In previous studies, an assumption has been made that diabetes may be either a risk factor or a symptom of pancreatic cancer. To investigate this connection, researchers examined both linear …
Read More »Lower Mood and its Association with Risk Factors of Type 2 Diabetes
Low mood in healthy children is associated with poorer metabolic health independently of adiposity… Mood comprises two main traits – positive and negative affect, both associated with depression and anxiety. Studies in children have linked depression with obesity, but the association with metabolic health is unclear. Researchers from Plymouth University …
Read More »Anemia and Much Older Type 2 Diabetes Patients
Anemia is higher in older type 2 diabetes patients… The chances of an anemia diagnosis increase with age and it affects roughly about 10% of those 65 years of age or older. In diabetes patients, the probability of diagnosing anemia could be two to threefold higher and furthermore, from previous …
Read More »New Enzyme Inhibitor May Prevent Onset of Type 2 Diabetes
The new drug apparently works by stabilizing metabolites of an omega-3 fatty acid called DHA… Researchers Bruce Hammock at the University of California, Davis, and Joan Claria at the University of Barcelona found that an enzyme called soluble epoxide hydrolase, or sEH, inhibitor both prevented the onset of diabetes and …
Read More »Type 2 Diabetes Linked with Colorectal Cancer
A longer duration of obesity also increased risk of colorectal cancer for diabetic patients… Dutch researchers have assessed the risk of colorectal cancer associated with type 2 diabetes, as compared with a nondiabetic reference population. They conducted an observational population-based cohort study within the Clinical Practice Research Datalink (1987–2012). All …
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