Diabetic patients can lose weight with medication specific for weight loss... In two randomized, double-blind and placebo-controlled studies, the safety and efficacy of treatment with phentermine (PHEN) and topiramate ER (TPM ER) (Qsymia) plus lifestyle for weight loss and glycemic benefits were measured. The studies included obese/overweight adults with type 2 diabetes. …
Read More »Beloranib Demonstrates Weight Loss in Hypothalamic Injury-Associated Obesity
The drug, a first-in-class MetAP2 inhibitor, was well-tolerated and also improved cardiovascular disease risk factors… Zafgen has announced that ZAF-221, a randomized, double-blind, placebo-controlled Phase 2 clinical trial of beloranib, a MetAP2 inhibitor, in 14 adults with hypothalamic injury associated obesity, or HIAO, met the primary efficacy endpoint of weight …
Read More »Dr. Timothy Garvey on Qsymia and Other New Therapies for Weight Loss
Steve Freed: Let’s start out with a little background about Qsymia and Belviq. What is the FDA allowing you to treat with the drugs? Dr. Timothy Garvey: In 2012, the FDA approved two new weight loss medications. In 2014, another medication was approved. That is three new medications. We hope …
Read More »Mortality Rates for Type 1 Diabetes Patients Still Too High
Despite major advances in the treatment of type 1 diabetes over the past 30 years, type 1 men are living approximately 11 fewer years than their non-diabetic peers. For women, the years lost is even higher at 13…. Scottish researchers examined data from a prospective cohort of patients in Scotland …
Read More »Intensive Therapy Lowers All-cause Mortality Rates for Type 1’s
An examination of 27 years of follow-up data from the EDIC study reveals that intensive glycemic therapy was associated with a modestly lower all-cause mortality rate…. After the DCCT (1983-1993) ended, participants were followed up in a multisite (27 US and Canadian academic clinical centers) observational study (Epidemiology of Diabetes …
Read More »Lifestyle Interventions to Prevent Diabetes Prove Cost-Effective
Using a computer model to analyze data from the 2003-2010 NHANE survey, researchers found that significant cost savings could be made if prediabetes patients made lifestyle changes… The Community Preventive Services Task Force recommends combined diet and physical activity promotion programs for people at increased risk of type 2 diabetes, …
Read More »Many Type 2 Patients Discouraged from Taking Metformin
Amending the label for metformin could open up the drug to a million more patients… Researchers from Penn Medicine and Weill Cornell Medical College report this week in a published research letter that, many patients with type 2 diabetes in the United States may be discouraged from taking metformin — …
Read More »Two MicroRNAs Identify Prediabetes
Serum levels of 2 microRNAs, miR-192 and miR-193b, can be used to identify individuals with prediabetes, researchers report… The uncontrolled hyperglycemic excursions associated with prediabetes are stressful for the body, and miRNAs are thought to be critical regulators of stress. Dr. Marcelina Párrizas from Diabetes and Obesity Research Laboratory, Barcelona, …
Read More »Low Birth Weight Increases Type 2 Diabetes Risk
A number of related factors could alert physicians to a greater likelihood that a patient who had low birth weight is at greater risk… A new study of more than 3,000 women confirms that low birthweight predicts an increased risk of type 2 diabetes in adulthood and reports which intermediating …
Read More »Obesity Not Unhealthy for Some
Obesity does not always go hand in hand with metabolic changes in the body that can lead to diabetes, heart disease and stroke, according to a new published study… In a study at Washington University School of Medicine, researchers found that a subset of obese people do not have common …
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