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Xultophy

  The first insulin/incretin mimetic combination launched overseas, Xultophy is a prefilled pen containing a fixed-ratio combination of insulin degludec and liraglutide, licensed in Europe for the treatment of type 2 diabetes in combination with oral hypoglycemics. Xultophy is the first product to combine a basal insulin and an incretin mimetic …

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Diabetes Mellitus 101 for Cardiologists, Part 11

In this week’s Homerun Slides, we cover the importance of the Incretin Effect with an examination of the mechanisms of action of GLP-1 agonist and DPP-4 inhibitor drugs including the cardioprotective aspects of these medications…. To download these slides in PowerPoint (.ppt) format, use this link: Diabetes Mellitus 101 for Cardiologists, Part 11 …

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Handbook of Diabetes, 4th Ed., Excerpt #23: Skin and Connective Disorders in Diabetes

handbook-of-diabetes-image

Rudy Bilous, MD, FRCP Richard Donnelly, MD, PHD, FRCP, FRACP Diabetes affects the cellular biochemistry of skin and connective tissues, in particular collagen synthesis and struc­ture, as well as cutaneous microvascular blood flow. Several non-infective skin conditions are associated with type 1 and/ or type 2 diabetes (Box 24.1). Diabetic dermopathy (‘shin …

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Adverse Outcomes Up with High A1c in Late Pregnancy for Type 1 Women

An HbA1c of 6.5-6.9% at 26 weeks’ gestation correlated with significantly elevated risk of preterm delivery, preeclampsia, need for neonatal glucose infusion, and a composite adverse outcome… Michael J.A. Maresh, M.D., from St. Mary’s Hospital in Manchester, U.K., and colleagues conducted a prospective assessment involving 725 women with type 1 …

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Simple Breath Test May Aid Early Diagnosis in Children

Increased breath acetone was linked to increases in beta hydroxybutyrate (a ketone) levels in the blood… Researchers may have identified a chemical marker for type 1 diabetes in the breath of children. Around 1 in 4 children with type 1 diabetes are unaware they have a condition until they develop …

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