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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #28: Insulin Gene Expression and Biosynthesis Part 4 of 6

Insulin biosynthesis: the previous section outlines that insulin gene transcription is a highly controlled process. The product of this process, pre-proinsulin mRNA, is unusually stable in pancreatic beta cells and it is further stabilized as glucose concentrations increase. As such, there is normally an abundant source of preproinsulin mRNA in the beta-cell cytosol available for translation.

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We Need Your Help: Interview Formats

Do you prefer to watch our video interviews with recognized diabetes doctors and experts, or read transcriptions of the interviews? 1) Videos 2) Transcripts 3) Both Please let us know -- follow the link to respond!

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Question #837

Test Your Knowledge

The list below indicates the ethnicities of the patients whose cases you have just reviewed over the past month. Please choose the correct order showing the relative risk of developing diabetes for each ethnicity in adults 20 years and older. Select one answer: [A] Non-Hispanic blacks, Hispanic, non-Hispanic whites, Asian American [B] Hispanic, Non-Hispanic blacks, non-Hispanic whites, Asian American [C] Non-Hispanic blacks, Hispanic, Asian American, non-Hispanic whites [D] Hispanic , Non-Hispanic blacks, Asian American, non-Hispanic whites Are you right? Follow the link to respond!

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Where There’s One Autoimmune Disorder, There May Be Another

Male, 32 years of age, type 1 diabetes, was following gluten free diet of his own choice. Was never diagnosed, just "feels better" when he doesn’t eat gluten. Has lab tests that were negative for celiac in the past. Came to see me for follow up diabetes education. Noted weight loss of 5 pounds in one week. Glucose levels were not elevated, in fact for the most part in target range.

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