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A 23-year-old athletic, nonobese man presents with a low-density lipoprotein cholesterol (LDL-C) level of 196. He reports that he's recently been eating more "bar food." Both his parents have high cholesterol, and his father had a myocardial infarction at age 41 y. His physical exam is notable for bilateral corneal arcus and Achilles tendon xanthomas. What's the best treatment option? A. Treat with diet B. Treat with diet + exercise C. Treat with diet + exercise + low-intensity statin D. Treat with diet + exercise + high-intensity statin Did you get it right? Follow the link to see!

Would you treat a patient with an A1c of 5.7-5.9%, who has diabetes in their family history and is a few pounds overweight with elevated cholesterol, with metformin along with diet and exercise, or just diet and exercise to get started? 1) Just diet and exercise to start 2) Diet and exercise along with metformin 3) Wait until their A1c is higher 4) Other Follow the link to share your opinion!

Female, 58 years of age, type 2 diabetes, obesity, taking (Qsymia- phentermine/topamax) for weight loss, antihypertensive for hypertension, and metformin for glucose management. Blood pressure usually in the 120-130/70-80 range, glucose averages ~120, and was losing weight. Today’s b/p 170/90, random glucose 232, c/o tinnitus. Weight was up 5 pounds since last seen 3 months ago. It’s now allergy season. After further discussion, she told me she was started on a medrol dosepak, and on her own purchased and is taking an OTC allergy medication.

In part 3 of this Exclusive Interview, Michael Hill explains the accuracy, fixed rate and insulin delivery delay of the Minimed 670G System.

In this week's Homerun Slides, takeaways from the EMPA-REG Trial with empagliflozin, the LEADER Trial and the SUSTAIN-6 Trial.

Acute regulation of gluconeogenesis: Prior to discovery of the transcriptional mechanisms described earlier, the control of hepatic glucose metabolism was examined in great detail on the basis of substrate, allosteric, and posttranslational modification. These factors alter gluconeogenic flux rapidly (seconds to minutes) and are a critical first response to increased glucose demand.

Theory proposed that type 2 diabetes can be reversed in the short term with medical approaches over bariatric surgeries.

Changes in gut microbiome may improve blood glucose levels in obese

Continuous glucose monitoring may reduce hypoglycemia fear.

Study reported SGLT2 Inhibitors monotherapy might not lead to DKA events as opposed to insulin therapy.