Would you feel comfortable using a combination treatment of a GLP-1 receptor agonist and a SGLT-2 inhibitor for a patient who has not reached goal? Follow the link to respond.

In this week's Homerun Slides, asking the question of how to translate knowledge and implications of pathophysiology, progression, and diabetes complications to the prevention, early diagnosis and optimal treatment of diabetes and its complications.

Normal glucose homeostasis: Any discussion of the pathogenesis of type 2 diabetes mellitus (T2DM) must start with a review of mechanisms involved in the maintenance of normal glucose homeostasis in the basal o postabsorptive state (10–12-h overnight fast) and following ingestion of a typical mixed meal. In the postabsorptive state the great majority of total body glucose disposal takes place in insulin independent tissues.

New meta-analysis striving to expand on the notion that glycemic control and stroke risk are closely associated.

Sotagliflozin to be reviewed by the FDA as possible oral adjunct for people with insulin-treated type 1 diabetes.

Discrepancies prompt additional analyses of ACCORD-BP and SPRINT studies to determine best blood pressure target for those with diabetes.

Detection of euglycemic ketoacidosis could be a challenge for physicians since this condition can mask an underlying diabetic ketoacidosis.

With more than 8 trillion text messages sent worldwide every year, self-management support for blood glucose (SMS4BG) has potential to help improve glycemic management of patients who have diabetes.

Data from DIAMOND trial to help determine if CGM helps those with consistently high glucose.

Mr. Carlson is a man, 52-years of age. He is Caucasian and works as a grocery store manager. His labs show that they were significant for elevated random plasma glucose 166 mg/dL, A1C 7.6% and elevated lipids (TG=175 mg/dL, LDL 148 mg/dL, HDL 38 mg/dL, total cholesterol 221 mg/dL). His physical exam is notable for central abdominal obesity (waist circumference 42”), BP 147/91, HR 72, RR 18, BMI 36 kg/m2, but otherwise normal. He is started on metformin and a dietitian is recommended. The dietitian discusses with him the benefits of medical nutrition therapy on weight, glycemic control, blood pressure, lipid profile, and overall wellbeing. Which following statement regarding macronutrients is true? A. The ratio of carbohydrates, protein and fat is the same for all patients. B. Total calories consumed per day is the key strategy for achieving glycemic control. C. Reduced intake of trans fat lowers the HDL and raises the LDL. D. Saturated fat should be less than 7% of total calories. Follow the link for the answer.