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Production Assistant, Diabetes In Control

International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #140: The Genetics of Type 2 Diabetes Part 2

Heritability of T2DM: It has long been clear that T2DM clusters in families and it is well established that the risk of developing T2DM depends on both genetic and environmental factors. However, the exact proportion of the two, that is, the heritability, is difficult to determine and heritability estimates therefore vary in the range of 25–80% between studies. Twin-studies have estimated the genetic component by comparing disease concordance in dizygotic twins with concordance in monozygotic twins. In these studies probandwise concordance rates (number of affected twins having a diabetic co-twin) for monozygotic twins vary between 34 and 100%.

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What NOT to Do When Your Patient is a Colleague

Health care professionals who are endocrinologists, cardiologists or who work in these specialized fields know the complications of prediabetes or diabetes. Many of us have these patients. Sometimes it’s almost natural to talk with these patients differently than we’d talk with most of our patients who aren’t as well-educated. A woman, 59 years of age with prediabetes and strong history of cardiovascular disease complained of a slight chest pain not associated with exertion or shortness of breath, just an ongoing discomfort. Other than this, the patient — who is herself a health care provider —  is feeling fine.

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