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Two Shots a Year for Hypertension? How RNA Silencing Could Transform Cardiometabolic Care

RNAi hypertension diabetes therapy concept showing an investigational injection, blood pressure monitor, liver, heart, and kidneys.

Poor medication persistence remains one of the hardest barriers to long-term blood pressure control. For people with diabetes, the stakes are especially high because hypertension adds to cardiovascular and kidney risk. Now, research into RNAi for hypertension in people with diabetes is raising an intriguing possibility: could an injection given …

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GLP-1s and Vision Loss: What Prescribers Should Know About the Emerging NAION Signal

Patient eye with semaglutide injection illustrating the potential GLP-1 NAION risk and sudden vision loss.

GLP-1 receptor agonists have transformed type 2 diabetes and obesity treatment, but a rare vision safety signal deserves clinicians’ attention. Emerging evidence has raised concerns about a potential NAION risk with GLP-1 therapy, particularly with semaglutide (Ozempic, Rybelsus, and Wegovy). Non-arteritic anterior ischemic optic neuropathy (NAION) can cause sudden, usually …

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Why Are We Ignoring the Gold Standard for Healing Diabetic Foot Ulcers?

Clinician applying a knee-high offloading device to help treat a diabetic foot ulcer and reduce plantar pressure.

Diabetic foot ulcer offloading is one of the most important parts of treating a neuropathic plantar ulcer, yet the most effective approaches are still not routinely used. Non-removable knee-high devices, including total contact casts and non-removable walkers, can reduce damaging pressure while supporting wound healing. So why does a treatment …

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When Diabetes Technology Damages the Skin: Keeping Patients on CGMs and Insulin Pumps

CGM skin irritation around a continuous glucose monitor and insulin pump adhesive sites

Continuous glucose monitors (CGMs) and insulin pumps can transform diabetes management, but the technology only works when patients can comfortably keep wearing it. CGM skin irritation can turn a valuable device into a daily source of itching, redness, pain, or damaged skin. In some cases, the reaction becomes severe enough …

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Your Eye Exam May Be Predicting More Than Vision Loss: AI Is Finding Hidden Diabetes Risks

Retinal AI analysis identifying cardiovascular, kidney, and metabolic risks in a patient with diabetes

For people with diabetes, a retinal photograph has traditionally answered one major question: Is diabetic retinopathy developing? However, artificial intelligence is beginning to uncover much more. Emerging retinal AI models for systemic risk assessment can detect patterns associated with cardiovascular disease, kidney disease, blood pressure, and metabolic health. As a …

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LDL Is Under Control—So Why Is Heart Risk Still High? Solving the Lipoprotein(a) Puzzle

Lipoprotein(a) screening in diabetes showing a blood test, glucose meter, heart, and artery to illustrate residual cardiovascular risk.

For many people with diabetes, lowering LDL cholesterol is a major part of preventing heart attack and stroke. Yet an important clinical puzzle remains. Why do some patients experience cardiovascular events even after LDL reaches recommended targets? Growing evidence points toward lipoprotein(a), or Lp(a), as one possible piece of that …

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Could a Stool Test Predict Your Patient’s Best Diabetes Medication?

Stool sample testing for gut biomarkers in diabetes to explore personalized medication response and precision diabetes treatment.

Could a stool sample someday help clinicians choose a diabetes medication before writing the prescription? Emerging research into gut biomarkers in diabetes is moving that possibility closer to clinical reality. Rather than simply cataloging which bacteria live in the intestine, researchers are examining microbial genes, stool-derived metabolites, and functional signatures …

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Can AI and Digital Pathology Detect Diabetic Kidney Disease Earlier?

Artificial intelligence analyzing a digital kidney biopsy slide for early detection and classification of diabetic kidney disease in a pathology laboratory.

Artificial intelligence is rapidly changing how healthcare professionals diagnose disease. But can computers identify kidney damage before it becomes obvious under a microscope? Researchers believe the answer may be yes. The combination of digital pathology, artificial intelligence, and diabetic kidney disease research is opening new opportunities to identify microscopic kidney …

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The Return of Aldose Reductase Inhibitors: Could an Old Idea Finally Pay Off?

A hand holding a diabetes medication tablet in front of an anatomical heart illustration with diabetic complication icons representing the nerves, retina, kidneys, and polyol pathway research.

Diabetes care has advanced dramatically over the past decade. While therapies such as GLP-1 receptor agonists and SGLT2 inhibitors have transformed glucose management and cardiovascular outcomes, many patients continue to develop long-term complications. Could an older therapeutic target finally provide the missing piece? Interest in aldose reductase inhibitors for diabetes …

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Your LDL Is Normal—So Why Is Your Heart Risk Still High?

Illustration of cholesterol plaque building inside an artery alongside a blood lipid test, highlighting remnant cholesterol as a hidden cardiovascular risk factor in people with diabetes despite normal LDL cholesterol.

For years, lowering LDL cholesterol has been the cornerstone of preventing heart disease in people with diabetes. Statins and other cholesterol-lowering therapies have dramatically reduced cardiovascular events. Yet many patients continue to experience heart attacks, strokes, or other cardiovascular complications despite reaching recommended LDL cholesterol goals. Why does this happen? …

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