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Insulin action dynamics: Insulin sensitivity from the clamp is expressed in terms of the steady-state value reached after a period of hyperinsulinemia. A dose–response can be constructed and sensitivity can be expressed as the ED50, that is, the concentration for half-maximal stimulation of Rd as a function of dose. Alternatively, sensitivity can be expressed (as it usually is) as the Rd at a specific dose of insulin, which may be low, intermediate, or a maximum dose. It is often assumed that steady-state rate of glucose uptake is reached by 180 min after onset of the insulin infusion. In fact, steady-state glucose uptake is not reached at 3h. Glucose uptake rate at 3h is only 2/3 the “true” steady-state, which is not achieved until 6h. Certainly, shorter periods (e.g. 120 min) are inadequate to reflect steady-state rates of uptake.

I have been writing columns—mostly about physical activity and exercise—for this enewsletter for more than a decade, and I am grateful to DIC for allowing me to educate everyone on topics that I feel so strongly about. This month, I would like to switch gears a bit and share some of my personal story about why physical activity matters to me and how I have lived successfully with type 1 diabetes for almost 50 years to date.

Increase in BMI and A1c leads to coronary issues.

Only 6% of PCP’s were able to identify 11 prediabetes risk factors (there are actually 13) that would prompt them to screen patients under the ADA guidelines according to a new study. Are you any better?

Long-term uncontrolled glycemic levels primary cause of complication.

A 72-year-old patient arrives in your office complaining of shakiness and sweating before he went to bed the previous night. He doesn’t recall checking his blood glucose level at the time, however he felt better after a glass of milk and a few graham crackers. His current medications are metformin, pioglitazone, and glyburide. Which one of the following medications is the most likely cause of his symptoms? 1) Metformin 2) Pioglitazone 3) Glyburide Follow the link to see the right answer.

Do you know the 13 risk factors for prediabetes? 1) Yes 2) No 3) Not sure (See article #3)

Dr. Elizabeth Buschur, MD is an assistant professor at The Ohio State University in Columbus, Ohio. She has implemented and is the director of the Diabetes Transition Clinic at the Nationwide Children’s Hospital as well as the Endocrine Disorders in Pregnancy Clinic at The Ohio State University. She presents CGM Use in Pregnancy and Special Populations at the AACE meeting.

In this Exclusive Interview, Dr. Elizabeth Buschur talks with Diabetes in Control Publisher Steve Freed during the AACE meeting in Austin, Texas about her AACE presentation, CGM Use in Pregnancies and Special Populations.

Dr. Buschur discusses her work at The Ohio State University and her specialized clinics in endocrine disorders and pregnancy, as well as a type 1 diabetes transition clinic at Nationwide Children’s Hospital.