Excessive weight gain due to intensive therapy can lead to increased cardiovascular risk factors.

Post-hoc analysis of the breakthrough EMPA-REG Outcome trial demonstrated reduction in composite cardiovascular outcomes that can be seen with empagliflozin therapy.

Study shows that good periodontal health is necessary to achieve a favorable glycemic status.

Would you vote for Medicare for All? Follow the link to share your opinion.

Mrs. O’Doole is a 34 year-old of Irish descent. She works as a florist and is married with three children. She arrives at your clinic for her annual wellness exam. Her blood pressure is 130/84 mmHg, pulse 65, BMI 24 kg/m2 and her physical exam is notable for acne and mild hirsutism. Her only current medication is oral birth control pills. She recalls starting OCP, 15 years prior, due to irregular menses. Based upon her medical history and physical, you believe it would be prudent to screen Mrs. O’Doole for type 2 diabetes. The lab returns a fasting plasma glucose (FPG) of 112 mg/dL. You share these results with your patient and inform her that while only mildly elevated, she has impaired fasting glucose. You recommend that she see a diabetes educator to help her modify her diet and exercise to lose some weight. At a follow-up appointment 6 months later, Mrs. O’Doole tells you despite good intentions, she has not been able to adhere to any meaningful lifestyle changes. In fact, she has gained 5 pounds. At this time, her repeat fasting plasma glucose shows FPG 138 mg/dL. After discussing management options with her, you decide the best management would be: A. lifestyle modifications only B. metformin only C. metformin + continue with lifestyle modifications D. repaglinide only Follow the link for the answer.

In this week's Homerun Slides, a closer look at the causes of hypertension with a special focus on Grave's Disease.

Other OSA comorbidities: Road traffic accidents -- Several cross-sectional studies using driving simulators showed worse driving performance and increased risk of road traffic accidents in patients with OSA. In a sample of 913 employed adults whose motor vehicle accident history was obtained from a statewide database covering the period 1988–1993, men with OSA were more likely to have at least one accident in 5 years compared to those without OSA.

Risk of diabetes diagnosis higher in those who lost weight after age 25, but study finds result statistically insignificant.

Men and women with type 2 have different risk for obesity-related cancer when compared with general population.

Protecting the heart and helping to reduce mortality, study takes closer look at beta-adrenoceptor inhibition in diabetes.