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Tag Archives: teplizumab

Can Weight Loss Delay Type 1 Diabetes? What the Pre-Symptomatic Data Really Show

Healthy food, exercise shoes, glucose meter, scale, and pancreas illustration representing weight and type 1 diabetes prevention research.

Efforts to prevent or delay type 1 diabetes have traditionally focused on the autoimmune attack that destroys insulin-producing beta cells. However, emerging research suggests metabolic stress may also influence how quickly vulnerable people progress to clinical disease. A 2026 TrialNet analysis found that autoantibody-positive people with overweight or obesity who …

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The Honeymoon Phase Won’t Last Forever: Are We Doing Enough to Preserve Beta Cells?

Hourglass beside a healthy pancreas illustration with insulin syringe and glucose meter representing beta-cell preservation during the type 1 diabetes honeymoon phase.

Receiving a diagnosis of type 1 diabetes can feel overwhelming. Yet for many adults, the weeks or months that follow bring an unexpected twist. Blood glucose levels often become easier to control, insulin needs decrease, and some people wonder if their diabetes is actually improving. This temporary period is known …

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The First Disease-Modifying Treatment After a Type 1 Diabetes Diagnosis: Why Teplizumab Is Changing the Conversation

Pediatric endocrinologist discussing teplizumab treatment options with a family following a new type 1 diabetes diagnosis.

For decades, treatment after a type 1 diabetes diagnosis focused almost entirely on insulin replacement and blood glucose management. While advances in technology have improved care, clinicians have had few ways to address the autoimmune process driving beta-cell loss. That is beginning to change. With the FDA’s expansion of teplizumab-mzwv …

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A Positive Type 1 Diabetes Screen Isn’t Always Equal: Why IA-2 Changes the Risk Calculation

Clinical illustration showing IA-2 autoantibody testing, type 1 diabetes risk assessment, blood sample analysis, and patient monitoring strategies used in islet autoantibody screening risk stratification.

As population-based screening for type 1 diabetes (T1D) becomes more common, clinicians increasingly encounter positive islet autoantibody results in children and adults who have no symptoms. However, not all positive screening results carry the same clinical significance. A single positive autoantibody may indicate elevated risk, yet the specific antibody detected …

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Type 1 Diabetes Prevention in Younger Patients: What New Data Mean for Screening

Pediatric doctor discussing early screening and type 1 diabetes prevention with a mother and child in a clinical setting

Can we actually prevent type 1 diabetes before symptoms appear? Increasingly, the answer is yes. As research evolves, clinicians now have stronger tools to identify at-risk children earlier and delay disease progression. This shift is especially important because type 1 diabetes often develops silently before diagnosis. Therefore, early screening and …

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