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Tag Archives: GLP-1 receptor agonists

GLP-1s and Opioids: The GI Risk Clinicians May Be Missing

GLP-1 medications and opioid therapy representing potential gastrointestinal risks from concurrent treatment.

GLP-1 receptor agonists have transformed the treatment of type 2 diabetes, but their effects on gastrointestinal motility remain an important clinical consideration. Opioids can also slow gastrointestinal function, raising an obvious question: what happens when patients need both? New research examining GLP-1 and opioid interactions suggests that opioid choice may …

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GLP-1s and Vision Loss: What Prescribers Should Know About the Emerging NAION Signal

Patient eye with semaglutide injection illustrating the potential GLP-1 NAION risk and sudden vision loss.

GLP-1 receptor agonists have transformed type 2 diabetes and obesity treatment, but a rare vision safety signal deserves clinicians’ attention. Emerging evidence has raised concerns about a potential NAION risk with GLP-1 therapy, particularly with semaglutide (Ozempic, Rybelsus, and Wegovy). Non-arteritic anterior ischemic optic neuropathy (NAION) can cause sudden, usually …

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Could a Stool Test Predict Your Patient’s Best Diabetes Medication?

Stool sample testing for gut biomarkers in diabetes to explore personalized medication response and precision diabetes treatment.

Could a stool sample someday help clinicians choose a diabetes medication before writing the prescription? Emerging research into gut biomarkers in diabetes is moving that possibility closer to clinical reality. Rather than simply cataloging which bacteria live in the intestine, researchers are examining microbial genes, stool-derived metabolites, and functional signatures …

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Your LDL Is Normal—So Why Is Your Heart Risk Still High?

Illustration of cholesterol plaque building inside an artery alongside a blood lipid test, highlighting remnant cholesterol as a hidden cardiovascular risk factor in people with diabetes despite normal LDL cholesterol.

For years, lowering LDL cholesterol has been the cornerstone of preventing heart disease in people with diabetes. Statins and other cholesterol-lowering therapies have dramatically reduced cardiovascular events. Yet many patients continue to experience heart attacks, strokes, or other cardiovascular complications despite reaching recommended LDL cholesterol goals. Why does this happen? …

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Could a Mini Pancreas Predict Which Diabetes Drug Will Work Best?

Scientist holding a patient-derived pancreatic organoid in a laboratory with a pancreas model and advanced research equipment, illustrating precision diabetes medicine.

Finding the right diabetes medication often involves trial and error. One patient may respond well to a GLP-1 receptor agonist, while another sees little benefit from the same treatment. As a result, clinicians frequently adjust medications before finding the most effective option. What if doctors could test a patient’s response …

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The Future of Diabetes Research: Why Adaptive Clinical Trials Are Changing Drug Development

Researchers reviewing adaptive clinical trial data for new diabetes therapies using digital analytics in a modern clinical research laboratory.

Diabetes research has advanced rapidly over the past two decades, leading to groundbreaking medications such as GLP-1 receptor agonists, SGLT2 inhibitors, and dual incretin therapies. However, one challenge remains constant: developing new treatments through traditional clinical trials is often expensive, time-consuming, and inflexible. Could there be a better way to …

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Can Your Patient’s DNA Predict Which Diabetes Drug Will Work Best?

DNA double helix beside diabetes medications and a blood glucose meter illustrating precision medicine and pharmacogenomics in diabetes treatment.

Imagine prescribing the same diabetes medication to two patients with nearly identical A1C levels, only to see one achieve excellent glycemic control while the other experiences little benefit or troublesome side effects. This scenario is common in diabetes care and highlights an important question: could genetics explain these differences? Growing …

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When Cardiology Meets Endocrinology: Why Diabetes Care Is Becoming a Team Sport

Multidisciplinary healthcare team including a cardiologist and endocrinologist collaborating on diabetes management with cardiovascular risk assessment in a modern clinical setting.

Not long ago, diabetes management focused primarily on controlling blood glucose levels. Today, that approach has evolved dramatically as cardiologists and endocrinologists increasingly work together to reduce cardiovascular risk. Thanks to groundbreaking cardiovascular outcome trials (CVOTs), clinicians now understand that treating type 2 diabetes means protecting the heart, kidneys, and …

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Amylin Is Making a Comeback: Why This Forgotten Hormone Is Back in the Spotlight

Medical illustration showing amylin hormone activity alongside insulin therapy, highlighting next-generation amylin-based treatments for diabetes and obesity.

For years, glucagon-like peptide-1 (GLP-1) receptor agonists have dominated conversations about diabetes and obesity treatment. However, another hormone is quietly returning to the spotlight. Amylin diabetes therapy is making a comeback as researchers develop a new generation of drugs designed to improve blood glucose control and support weight management. Amylin …

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When Weight Loss Isn’t the Whole Story: Managing Binge Eating Disorder in Type 2 Diabetes

Healthcare professional counseling an adult with type 2 diabetes about binge eating disorder, with healthy foods, a glucose meter, and balanced meal planning on a table.

For many people living with binge eating disorder and type 2 diabetes, managing blood sugar isn’t just about counting carbohydrates or losing weight. Emotional eating, loss of control around food, and feelings of guilt can quietly interfere with diabetes care, even when someone is taking the right medications. Because of …

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