Bone & Joint

Risk warning, precaution added to labels of all drugs in this class…   FDA warned recently that DPP-4 inhibitors could cause severe and disabling joint pain. The agency has added a new warning and precaution about this risk to the labels of all drugs in this class. If patients experience …

Lifelong condition may join list of various medical ailments for which type 1 patients are at an increased risk… A population-based cohort study published using data from The Health Improvement Network (THIN) was evaluated comparing records from 303,394 type 1 diabetes patients aged 0-89 years old with 303,872 random controls …

Accessible fruit offers variety of health benefits…. Incorporating papaya into your diet can have many possible health benefits. Studies suggest that consuming papaya decreases the risk of obesity, diabetes, and heart disease as well as promotes healthy skin and hair, increases energy and decreases overall weight. Papaya is very accessible …

This week we have the second part of our two-art interview with Dr. Janice Smiell, CMO at Alliqua BioMedical, Inc. Dr. Smiell, and we delve a little deeper into the specifics of this new technology to heal chronic wounds using placental biomaterials. Steve Freed: With all the testing that is …

Investigators are targeting individualized diabetes therapy using the genetic approach… Dr. Lazar and his team focused on a fat molecule called PPARγ, which is also the target for the thiazolidinedione (TZD) class of drugs. PPARγ binds to DNA and activates the expression of other genes. The researchers hypothesized that genetic …

A new study shows liraglutide mitigates the bone loss common with low calorie diets… Weight loss is frequently tied to reduced bone mass in adults who embark on a low calorie diet, putting them at increased risk of fractures following significant weight reduction. Furthermore, the reduction in bone mass does …

Benefits demonstrated in mice and yeast; piloted in humans….

David Levy, MD, FRCP      Erectile dysfunction This is the commonest neuropathic complication: 20% of men have erectile dysfunction (ED) at diagnosis, increasing to 34% at 12 years (UKPDS). The prevalence in a newly diagnosed Kuwaiti population was 30%, and nearly 50% in a large survey of Canadians attending their primary-care physicians …

David Levy, MD, FRCP      Mononeuropathies and other focal syndromes Peripheral mononeuropathies Upper limb Carpal tunnel syndrome (median nerve) Carpal tunnel syndrome is very common (remember the association with primary hypothyroidism, especially in type 1 diabetes) and may present with atypical symptoms, as it is often superimposed on diabetic polyneuropathy. Consider it …

David Levy, MD, FRCP      Charcot neuroarthropathy Charcot neuroarthropathy is a serious and poorly understood condition associated with rapid destruction of bones and joints and resulting in bone fragmentation. It occurs only in patients with advanced sensory and autonomic neuropathy, and is characteristic of long-duration type 1 diabetes with other microvascular complications, …