Transplants

Could study of FOXO transcription factors one day lead to new therapies?

The Diabetes Research Institute (DRI), a Center of Excellence at the University of Miami Miller School of Medicine, announced today that the first patient in its clinical trial has been free from insulin injections in record time following the implantation of islet cells within a biological scaffold. The patient, Wendy …

This week we have the second part of our two-art interview with Dr. Janice Smiell, CMO at Alliqua BioMedical, Inc. Dr. Smiell, and we delve a little deeper into the specifics of this new technology to heal chronic wounds using placental biomaterials. Steve Freed: With all the testing that is …

David Levy, MD, FRCP Renal replacement therapy The decision to start dialysis is often difficult. The clinical decision is based on many factors, including the presence of uremic symptoms and weight loss, and biochemical measurements including serum creatinine (e.g. serum creatinine 700–800 μmol/L(small mu), eGFR < 12–14 mL/min, falling albumin, hyperkalemia). …

Human embryonic stem cell therapy was recently shown to reverse type 1 diabetes in mice, and now new mouse studies suggest a role for stem cells in the treatment of type 2 diabetes… Obese, diabetic mice treated with a combination of transplanted stem cell-derived pancreatic progenitor cells and insulin-sensitizing drugs …

David Levy, MD, FRCP Introduction Insulin treatment in type 1 diabetes is substitution/replacement hormone treatment, but replacement is much more variable and difficult to achieve than in other hormone deficiencies (e.g. thyroid, adrenal, gonadal hormones) because of the minute-by-minute variation in insulin secretion by the intact pancreas, which cannot yet be …

Success in finding new stem cells that can produce insulin… Type 1 diabetes is caused by autoimmune disease that leads to the destruction of insulin producing beta cells in the pancreas. The destruction of beta cells in the pancreas can be treated by transplant of pancreatic beta cells or cadaveric …

Rudy Bilous, MD, FRCP Richard Donnelly, MD, PHD, FRCP, FRACP Diabetic nephropathy is a clinical diagnosis based upon the detection of proteinuria in a patient with diabetes in the absence of another obvious cause such as infection. Many of these patients will also be hypertensive, have retinopathy and, in advanced stages, renal …

Researchers believe that microbes may influence our decisions by releasing signaling molecules into our gut…. 

Results are promising but rejection rate is higher with deceased donor transplants….