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Combination of insulin, a GLP-1 receptor agonist and an SGLT-2 inhibitor effective, includes DKA risk.

Spouses or live-in partners of people newly diagnosed with diabetes twice as likely to develop diabetes…

Drug shows a significant reduction in HbA1c in patients with type 2 diabetes… A new investigational drug is underway to help with reduction of HbA1c, weight, and improve glycemic control in type 2 diabetes patients. ITCA 650 is an injection-free GLP-1 receptor agonist that provides continuous subcutaneous exenatide for 12 …

Peglispro allows slow insulin absorption, but associated with injection site reaction and increased ALT and triglycerides… Peglispro or pegylated lispro insulin is currently under phase III investigation for both type 1 and type 2 diabetes. The large hydrodynamic size of peglispro allows slow insulin absorption and reduces clearance, resulting in …

Sulfonylureas not associated with increased cardiovascular mortality, myocardial infarction and stroke in a meta-analysis of 47 randomized clinical trials… Sulfonylureas are relatively inexpensive and are important therapeutic agents in type 2 diabetes management. However, they are not widely used due to safety concerns regarding hypoglycemia and weight gain. Furthermore, it …

The two new injectable drugs, alirocumab and evolocumub, have been recommended for FDA approval by the agency’s Endocrinologic and Metabolic Advisory Committee.…

Fixed-dose insulin glargine/lixisenatide improves HbA1c levels in patients with type 2 diabetes…

GLP-1 analog also showed reduction in weight and incidence of hypoglycemia… Dulaglutide (Trulicity) is a glucagon-like peptide analog that is used once weekly to improve blood glucose level. During the open-label, multinational, parallel arm study, researchers compared the safety and efficacy of dulaglutide 0.75mg and 1.5mg to insulin glargine in …

Researchers are testing Medtronic’s 670G "hybrid-closed loop" system (insulin pump + Enlite 3 CGM sensor) in people with type 1 diabetes. Based on the Enlite 3 CGM reading every five minutes, the 670G pump’s software automatically increases/decreases insulin delivery to target a blood glucose of 120 mg/dl. The 670G algorithm …

Jackie Boucher discusses the complexities of individualizing nutrition and diet advice for diabetic patients including such factors as glycemic control, managing cholesterol and weight, lifestyle, socioeconomic and cultural conditions, and the patient’s readiness for change….