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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #81: Insulin Actions In Vivo: Glucose Metabolism Part 7 of 9

Cellular, biochemical, and molecular mechanisms of insulin action: The insulin receptor is a glycoprotein consisting of two alpha subunits and two beta subunits linked by disulfide bonds and expresses insulin-stimulated kinase activity directed towards its own tyrosine residues. Insulin receptor phosphorylation of the α subunit, with subsequent activation of insulin receptor tyrosine kinase, represents the first step in the action of insulin on glucose metabolism.

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Statins and Exercise: Revisited

I chronicled someone with type 1 diabetes whose ability to exercise was compromised by his use of statins back in April 2016. As you know, statins are a class of medications prescribed to lower cholesterol levels or abnormal levels of blood fats, with the goal being a reduction in the risk of heart attack and stroke. Brand name examples of statin medications include Altoprev, Crestor, Lescol, Lipitor, Livalo, Mevacor, Pravachol, and Zocor.

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