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Physical Activity and Inflammatory Markers in Prediabetes

May 8, 2021
Editor: David L. Joffe, BSPharm, CDE, FACA

Author: Brenda Oppong, PharmD Candidate, LECOM School of Pharmacy

A systematic review and meta-analysis of randomized controlled trials examines how some inflammatory markers may be affected by physical activity. 



Prediabetes is when the blood glucose level is more than a normal range but less than the range to confirm type 2 diabetes (T2DM). Prediabetes inflammatory stages are associated with an increased level of adipokines and pro-inflammatory cytokines. A pro-inflammatory state in prediabetes occurs predominantly because of the increase in insulin resistance. Physical activity is considered the first-line treatment for many disease states, and it is the first-line therapeutic strategy to treat prediabetes.  Previous studies have analyzed the impact of physical activity on glycemic levels and the resulting reduction in aggravation of prediabetes to T2D. The effect of lifestyle interventions like physical activity on different inflammatory markers has been documented in long-term clinical trials. A systematic review and meta-analysis were conducted to strengthen the evidence on the impact of physical activity promotion on inflammatory markers in prediabetes....


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