Diabetes In Control. A free weekly diabetes newsletter for Medical Professionals. News and information for Medical Professionals.
Letter from the Editor
A couple of weeks ago our exercise guru, Dr. Sheri Colberg, had a great article on how different types of exercise can either raise or lower or rapidly lower your glucose levels and what your patients could do about it.
This week our intern, Aleksandra Kusic, PharmD Candidate, Florida A&M University, College of Pharmacy, takes a deeper dive by looking at how HIIT exercise can have a long term positive effect on A1c. Reading her article may give you the knowledge to keep your patients strong, healthy, and prevent hypoglycemia.
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We can make a difference!
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Dave Joffe
Editor-in-chief
TOP STORIES — Diabetes News and Research
A first-of-its-kind study examines the differing effects of sucrose versus glucose intake on circulating glucagon-like peptide-1 (GLP-1).
Does a 12-week high-intensity interval training (HIIT) program show superior glucose control in type 1 diabetes than other forms of exercise?
Better oral health may be linked to better outcomes in patients with diabetes, but which comes first — gum disease or diabetes?
Did You Know? Functional Decline Tied to Prediabetes:
Individuals with diabetes mellitus are more likely to suffer from functional decline and disability than the general population. Still, studies have not previously looked at the association between prediabetes and these outcomes over time. This study used 12 years of data from the Swedish National Study on Aging and Care to assess the impact of both diabetes and prediabetes on physical function and disability progression, and further tests whether the presence of cardiovascular disease (CVD) mediates these impacts.
The researchers found that prediabetes is associated with physical functional decline regardless of whether a patient progresses to diabetes, with concurrent CVD particularly leading to accelerated disability progression. A cohort of 2,013 participants aged ≥60 from the Swedish National Study on Aging and Care participated in the study. At baseline, 650 (32.3%) had prediabetes, and 151 had diabetes (7.5%). In multi-adjusted mixed-effect models, prediabetes was associated with an increased chair stand time (β 0.33, 95% CI 0.05-0.61), a decreased walking speed (β -0.006, 95% CI -0.010 to -0.002), and an accelerated disability progression (β 0.05, 95% CI 0.01-0.08), even after controlling for the future development of diabetes. Diabetes led to faster functional decline than prediabetes. In mediation analyses, CVDs mediated 7.1%, 7.8%, and 20.9% of the associations between prediabetes and chair stand, walking speed, and disability progression, respectively.
From the results, it was concluded that prediabetes and diabetes are associated with faster functional decline and disability, independent of the future development of diabetes. This study highlights the importance of monitoring for practical reduction among patients with prediabetes, as well as controlling both hyperglycemia and CVD as a means to reduce progression to physical disability.
Diabetes Care 2021 Mar; 44(3): 690-698.
Diabetes in Control gratefully acknowledges the assistance of the following pharmacy doctoral candidates in the preparation of this week’s newsletters:
Macrina Ghali, PharmD Candidate 2021, Florida A&M University, College of Pharmacy and Pharmaceutical Sciences
Sameen Khan, Pharm.D. Candidate, USF College of Pharmacy
Aleksandra Kusic, PharmD Candidate, Florida A&M University, College of Pharmacy and Pharmaceutical Sciences
Arjay Mendoza, PharmD Candidate, University of Colorado Denver Skaggs School of Pharmacy and Pharmaceutical Sciences
Marianis Barreto Quintana, PharmD. Candidate, LECOM School of Pharmacy
Jacob Roberts, PharmD Candidate 2021 of University of Colorado Denver Skaggs School of Pharmacy and Pharmaceutical Sciences
Your Friends in Diabetes Care
Steve and Dave
Diabetes In Control
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