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Appetite-Regulating Hormones Lower After Sucrose Versus Glucose

Apr 10, 2021
Editor: David L. Joffe, BSPharm, CDE, FACA

Author: Marianis Barreto Quintana, PharmD. Candidate, LECOM School of Pharmacy

A first-of-its-kind study examines the differing effects of sucrose versus glucose intake on circulating glucagon-like peptide-1 (GLP-1).  

The intake of simple sugars is a major topic of concern. The proportion of daily energy consumed through fructose intake has increased rapidly, promoting obesity and metabolic syndrome. Researchers suggest that fructose intake will differentially change other simple sugar feeding methods, leading to weight gain. One of the basic fructose mechanisms in feeding is its intake of incretin and gut-derived hormones, affecting subjective hunger.  


Former investigations have determined that fructose's acute ingestion raises blood glucose and circulating insulin concentration, though to a lesser extent than glucose intake. The outcomes of fructose ingestion on these circulating hormones associated with regulating hunger may expose some of the relationships between increased dietary fructose and the development of obesity. However, fructose is usually not consumed in isolation, and there has been limited research into how real-world sugars like sucrose affect endocrine response. Sucrose, a.k.a. table sugar, is a disaccharide composed of equal parts glucose and fructose....

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