New preliminary data is in…. Sanofi, the maker of Lantus (insulin glargine), finished more phase III studies on their newest formulation of insulin glargine, U300, and discussed their results at the World Diabetes Congress 2013 in early December. The study results have not yet been published but researchers reported that the …
Read More »Insulin Pumps vs. Multiple Daily Injections (MDI): Which is Better?
Can insulin pumps reduce glycemic variability in type 1 diabetes?… A new cross-sectional observational cohort study looked at continuous subcutaneous insulin infusion (CSII), aka insulin pump, versus multiple daily injections (MDI) to determine which insulin delivery system resulted in less blood glucose variability in type 1 pediatric diabetes patients. Large …
Read More »ADA/JDRF Type 1 Diabetes Sourcebook, Excerpt #17: Insulin, Part 2 of 3
Anne Peters, MD, and Lori Laffel, MD, MPH, Editors Jane Lee Chiang, MD, Managing Editor PEDIATRICS – Jane Lee Chiang, MD, and Georgeanna J. Klingensmith, MD ADULTS – Irl B. Hirsch, MD 1. Basal insulin accounts for ~50% of total daily dose: i. LAA (insulin glargine, detemir, degludec) or NPH if LAA …
Read More »Insulin Initiation in Type 2 Patients
David Joffe, BSPharm, CDE, Editor-in-chief, Diabetes In Control In 2003, the Treat to Target Trial study results were published. The study compared the effectiveness of a patient mediated titration schedule with both NPH and glargine, and also whether patient titration was as good as a prescriber-based titration….
Read More »Understanding the U500 Strength, Conversion and Day’s Supply Conundrum
Humulin R U500 is a concentrated insulin that contains 5 times as many units of insulin per ml as U100. It is also dispensed in a 20 ml vial versus 10 ml for the U100. This often causes confusion for many clinicians, pharmacists, educators and pharmacy benefit plans when trying to …
Read More »Conversion Chart for Humulin R U-500 Insulin Dose
When using a U-100 insulin syringe or a tuberculin syringe, use this handy U-500 Conversion Chart. Humulin U-500 Conversion Chart Mar 2011
Read More »Weight-Based Insulin Dosing Safe at Recommended Doses
Weight-based insulin doses up to 0.6 units per kilogram are associated with a low risk of hypoglycemia, according to a new report….
Read More »Diabetes Disaster Averted #36: Mixing Insulins
Recently I saw a type 1 DM patient diagnosed in 1980 at 15 years of age. She had not seen an educator in quite some time but had changed from NPH/Regular to Lantus & Regular….
Read More »Diabetes Disaster Averted #20: Insulin Pumps and Waterbeds
I recently had a pump patient who suddenly started having a problem in the morning with hypoglycemia, 30 minutes after arising but prior to taking her bolus for her breakfast. We recommended she change her infusion set and insertion area however there was no improvement and she continued to have …
Read More »Determining Patients’ Insulin Sensitivity Factor
A formula to help your patients determine their Insulin Sensitivity Factor. In order for your insulin patients to make corrections for elevated blood sugars, they need to determine how sensitive they are to their insulin. This formula provides an easy way to find out how much insulin they need to …
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