Are you ready for the opening of a large can of worms, when it comes to classifying diabetes? We have all heard type one, type one and one half, type two, type 3, adult onset, MODY, LADA and many other ways of naming diabetes, and now top researchers and endocrinologists …

Type 1 diabetes (T1DM) is one of the most prevalent severe chronic diseases of childhood, affecting more than 170,000 children in the United States, an increase of 23% since 2001. In the US, more than 25,000 children are diagnosed annually with 1:200 children and 1:100 adults diagnosed with T1DM during the lifespan.

In this week's Homerun Slides, pathogenesis and biological interventions in autoimmune diabetes.

Mrs. O’Doole is a 34-year-old of Irish descent. She works as florist and is married with three children. She arrives at your clinic for her annual wellness exam. Her blood pressure is 130/84 mmHg, pulse 65, BMI 24 kg/m2 and her physical exam is notable for acne and mild hirsutism. Her only current medication is oral birth control pills. She recalls starting OCP, 15 years prior, due to irregular menses. What clinical diagnosis would suggest screening Mrs. O'Doole for type 2 diabetes? Follow the link to answer.

Since recent developments in the use of SGLT-2 inhibitors, are you positive or negative in recommending to your patients? Follow the link to respond.

In this week's Homerun Slides, the cardiovascular benefits of pioglitazone.

Impaired glucose tolerance (IGT) and impaired fasting glycemia (IFG) are categorized as stages in the natural history of disordered carbohydrate metabolism. They occur in all individuals as they progress from normal to diabetes, but since the transition through these states is rapid in type 1 diabetes, they are rarely identified in such individuals. Therefore, nearly all of the literature dealing with IGT and IFG is concerned with issues relating to type 2 diabetes, such as risk of developing type 2 diabetes and CVD.

Some think you can’t be too rich or too thin. A stylish female, type 2 diabetes, 46 years of age came into the office (a weight loss clinic) for a follow up. Everyone was telling her how great she looked. She said she was feeling great and excited because she could fit into clothes she couldn’t fit in the past few years. She lost 9 pounds in three months. She had not been self monitoring her glucose. She was thrilled, but her doctor wasn’t so thrilled, at least not yet. He was concerned her glucose was elevated.

What kind of results have you seen with the use of SGLT-2 inhibitors for your patients? Follow the link to respond.

Reasons may include poor metabolic control and extreme obesity.