In this week's Homerun Slides, the natural history of type 2 diabetes, the eight core defects implicated in the pathogenesis of type 2 diabetes, and the effects of treatment.

Type 1A diabetes results from a chronic autoimmune destruction of the pancreatic beta cells, probably initiated by exposure of a genetically susceptible individual to some environmental agent(s). This preclinical period is marked by the presence of autoantibodies to pancreatic beta-cell antigens such as insulin, GAD65 (Glutamic Acid Decarboxylase), ICA512 (called also IA-2) or ZnT8 (Zinc Transporter 8), and precedes the onset of hyperglycemia by a few years.

Safety and efficacy, adaptive control algorithm to be tested in U.S. and Europe.

β-cell centric classification of diabetes puts focus on single common denominator of all types.

New pen may improve glycemic control in people with severely insulin-resistant diabetes.

Current black box warning may be overstating the kidney risk.

New nutrition recommendations filled with numerous changes.

Surgery could lower patients' development of future medical issues.

Would you like to see a different classification for diabetes instead of type 1, type 2, type 1½, LADA, etc.? Follow the link to respond.

Mrs. O’Doole is a 34-year-old of Irish descent. She works as a florist and is married with three children. She arrives at your clinic for her annual wellness exam. Her blood pressure is 130/84 mmHg, pulse 65, BMI 24 kg/m2 and her physical exam is notable for acne and mild hirsutism. Her only current medication is oral birth control pills. She recalls starting OCP, 15 years prior, due to irregular menses. Based upon her medical history and physical, you believe it would be prudent to screen Mrs. O’Doole for type 2 diabetes. You discuss your recommendations with her and she agrees be tested. The lab returns a fasting plasma glucose (FBG) of 112 mg/dL. You share these results with your patient and inform her that, while only mildly elevated, she has impaired fasting glucose. What is the best choice for initial management of Mrs. O’Doole’s prediabetes? Follow the link to respond.