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Production Assistant, Diabetes In Control

International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #64: Mechanisms of Insulin Signal Transduction Part 8 of 8

Suppressor of cytokine signaling-3: Observations pertaining to suppressor of cytokine signaling-3 (SOCS-3) point to a new mechanism for insulin signal modulation. The SOCS family of proteins (CIS and SOCS 1 – 7) were originally described as a negative feedback loop for cytokine receptor signaling through Janus kinase (JaK).

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Question 874

Test Your Knowledge

Glucose-lowering drugs and insulin resistance: Which one of the following categories of glucose-lowering drugs improves insulin resistance as its primary mechanism of action? A. Sulfonylureas (e.g. glipizide) B. Thiazolidinediones (e.g. pioglitazone) C. GLP-1 receptor agonists (e.g. liraglutide) D. DPP-4 inhibitors (e.g. sitagliptin) E. SGLT-2 inhibitors (e.g. canagliflozin) Follow the link to see the correct answer!

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Insulin and Extreme Temperatures

We are reviewing a new product that can tell if your insulin has been exposed to extreme temperatures. So can you please answer the question: Have you had any patients whose insulin lost its effectiveness due to being exposed to extreme temperatures? Please follow the link to respond!

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Sugar Free, Gluten Free, And Vegan Are NOT Carb Free

Woman, 53 years of age. Type 2 diabetes and is obese. Patient’s daughter was getting married. She was very motivated to lose weight for the wedding and she did. Her A1C lowered from 7.5% to 6.6%. She cut back on her carbs to <100gm/day, increased her activity and took her metformin regularly. She lost 22 pounds over 6 months. The wedding was 2 months ago and she has gained 6 pounds. That may not seem like much, but it was enough to raise her A1C and open her eyes.

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