In this week's Homerun Slides, the safety warnings, precautions, and incorporation of SGLT-2 inhibitors into diabetes treatment.

Insulin resistance in humans: abnormalities in insulin signaling and in the glucose transport effector system Although the key elements of the insulin signaling network have been defined by studies employing molecular and cell biology techniques, a number of studies have focused on translating this knowledge to human studies in a clinical research setting. Insulin resistance in peripheral tissues characterizes obesity and T2DM, and is involved in the pathogenesis of diabetes.

New dual drug could be a diabetes breakthrough.

Current study in Lancet showed that patients reduced their A1c levels by 1.55%.

Only GLP-1 receptor agonist for use with mealtime or basal insulin for adults with type 2.

Even though amputation is not a major effect, it is still important to let patients know about it and how to prevent it with proper foot care.

As problems for Tandem continue, and with Johnson & Johnson abandoning the insulin pump market, it’s beginning to dawn on some people that we soon could live in a world with just two insulin pump companies – Medtronic and Insulet.

Therapy said superior to a basal/bolus insulin regimen at lowering HbA1c with less hypoglycemia and weight gain.

GLP-1 receptor agonists vs DPP-4 inhibitors: In head-to-head trials of dipeptidyl peptidase 4 (DPP-4) inhibitors vs glucagon-like peptide 1 (GLP-1) receptor agonists, GLP-1 receptor agonists showed more favorable outcomes in all of the following areas except which one of the following? A. Greater glycemic control B. Greater tolerability C. Greater weight loss D. Greater improvement in beta-cell function E. Greater reduction in postprandial triglycerides Follow the link to see if you got it right!

When was the last time you rode a bike? a) Days b) Weeks c) Months d) Years e) Decades ago f) Never! Follow the link to see how you compare to your colleagues!