Sometimes thinking out of the box really is necessary to find ways to help our patients. Rosalyn Sussman Yalow won a Nobel Prize for developing the radioimmunoassay technique that revolutionized drug molecule discovery. Her interest in unique compounds led her to order some gila monster saliva, and a few years …

In this week’s Homerun Slides, we continue our exploration of the positive effects of Ranolazine, which is used to treat angina, and then begin to focus in on therapies for type 2 patients with cardiovascular concerns… To download these slides in PowerPoint (.ppt) format, use this link: Diabetes Mellitus 101 for Cardiologists, Part …

Rudy Bilous, MD, FRCP Richard Donnelly, MD, PHD, FRCP, FRACP The vast majority of cases of diabetes in children are type 1, caused by autoimmune destruction of beta cells in the pancre­atic islets. A steady increase in the incidence of type 1 dia­betes has been reported worldwide (average increase 2.5-3% per year …

Janelle, an RN, is 36 years old with type 1 diabetes. She has a busy life between family and work. She eats healthy, exercises regularly, and wears a pump but occasionally has severe hypoglycemia, especially during exercise and at night. When I met her, I recommended she wear a continuous …

Change Talk: Childhood Obesity is a role-play simulation where you take the role of a healthcare provider and engage in a practice conversation with a virtual mother and her child. Through the conversation, you learn to apply Motivational Interviewing (MI) techniques to help them identify motivation for change, supporting them …

A new combination of two FDA-approved drugs has shown a remarkable 8.7% average weight loss and a reduction of 1 point for A1c in just 12 weeks…

Glargine 300 more effective than glargine 100 currently available… Two single-dose studies were conducted in Japan and Europe to compare the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of new insulin glargine 300 U/ml (Gla-300) and insulin glargine 100 U/ml (Gla-100) in people with type 1 diabetes mellitus. In two double-blind, randomized, crossover …

The GLP-1 agonist albiglutide was added to the regimen of patients already on metformin and glimepiride…

But the effects are modest and type 2 patients on metformin can do moderate exercise without undue fear of hypoglycemia… Before, during, and after a 45-min bout of exercise at 60% VO2max, glucose kinetics were determined by isotope tracer technique in patients with type 2 diabetes mellitus with metformin treatment …

Can metformin reduce the risk of cancer for those with type 2 diabetes?… In previous studies, metformin has been shown to decrease the risk of cancer in type 2 diabetes. A recent meta-analysis showed a 34% reduction in the incidence of any cancer and a 33% reduction in cancer mortality; …