Linkage studies identify regions of the genome that are shared more frequently than would be expected by chance by relatives affected by a particular disease. Most studies analyze affected sibling pairs and utilize genetic markers that are scattered throughout the genome at moderate density, typically microsatellites. A significant excess of allele sharing identical by-descent (IBD) in affected sibpairs suggests that the region containing the marker locus also contains a disease susceptibility locus. The first linkage scan for T1DM identified 20 chromosomal regions with suggestive evidence of linkage to disease, including the HLA and INS gene regions.

Improvement in HRQoL, fatigue for patients with persistent symptoms despite normal thyroid gland function

In this Exclusive Interview, Jeffrey Emmick talks with Diabetes in Control during the ADA 2018 convention about Lilly diabetes products in the pipeline.

In this Exclusive Interview, Jeffrey Emmick talks with Diabetes in Control Medical Editor Joy Pape (with a special appearance by Diabetes In Control Publisher Steve Freed) during the ADA 2018 convention in Orlando about Lilly's diabetes products in the pipeline.

In part 1 of this Exclusive Interview, Jeffrey Emmick talks with Diabetes in Control Medical Editor Joy Pape about various products Lilly has brought to market and new products in development.

In part 2 of this Exclusive Interview, Jeffrey Emmick talks with Diabetes in Control Medical Editor Joy Pape about the combination of GLP1s and SGLTs while Diabetes in Control Publisher Steve Freed makes a quick appearance to ask about the possible effects of their combined use.

Milder strain of flu has been most common cause of cases this flu season

Reduced risk seen for type 2 diabetes after adjustment for confounders

Thanks to everyone who asked for more information on the “sartan” contamination recall. Some of you asked how this happened, a few wanted to know the science behind it, and almost everybody wanted to know how the pharmaceutical industry and the FDA were going to fix it. With those comments …

Increased heart rate in people with CAD has shown to increase diagnosis risk despite BMI and blood pressure.