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International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #167: Molecular Genetics of Type 1 Diabetes Part 4

The CTLA4 gene on chromosome 2q33.2 encodes a transmembrane co-receptor expressed on the surface of T cells. This functions as a negative regulator of T-cell activation via interaction with the B7 molecule on antigen-presenting cells (Figure 30.3). The G allele of the +49A/G SNP in exon 1 of CTLA4 has been implicated as a susceptibility marker for T1DM, but was rejected as a causal SNP by a fine-mapping study, which showed that its effect could be explained by more strongly associated variants in a 6.1 kb noncoding region, 3′ of the gene.

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Tim Dunn 2018 Transcript

In this Exclusive Interview transcript, Tim Dunn talks with Diabetes in Control Publisher Steve Freed during the ADA 2018 convention in Orlando about Abbott's research on CGM use and how the FreeStyle Libre system is helping a variety of patients with diabetes.

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