In this week's Homerun Slides, the call for patient-centered approach to diabetes therapy that factors in the patient's individual cause of metabolic dysregulation.

Beta-Cell response to nonglucose secretagogues: Proteins and amino acids -- The insulinotropic effect of oral proteins was first described almost 50 years ago and recently confirmed. After the ingestion of a small amount of proteins (30–50 g) or a larger amount of proteins (2 g kg−1), plasma insulin was raised two- to threefold over baseline and remained persistently elevated for 90 or 240 minutes, respectively. In either case, blood glucose did not change, whereas both GLP-1 and GIP levels were raised threefold over fasting values.

Sometimes, when we want to impress our patients with the importance of their disease, we will list all the possible effects of the disease. These include blindness, kidney failure, and amputations. But what do we tell our patients that have pre-diabetes or impaired glucose tolerance? This week, we have an …

A study in Diabetes Care showed that 74.7% of deaths among patients with impaired glucose tolerance happened after progression to type 2 diabetes.

Adopting a Mediterranean diet in patients with diabetes helps improve glucose levels.

Is pioglitazone a viable option for patients with insulin resistance and recent stroke or myocardial infarction?

Can DPP-4 inhibitors and GLP-1 analogues cause bile duct and gallbladder complications?

A team of researchers at the University of Wisconsin School of Medicine and Public Health has identified the genetic cause for a rare syndrome in children with poorly controlled type 1 diabetes.

In part 3 of this exclusive interview, Dr. Faustman discusses how a cure based on the inexpensive BCG vaccine could permanently change type 1 treatment, and whether results could also apply to type 2.

In part 2 of this exclusive interview, Dr. Faustman discusses the challenges of dosing BCG correctly, and the difficulties of defeating autoimmunity in humans.