Every week we see patients who can’t tolerate metformin, and we often have to chose a less effective but more expensive medication for their diabetes. We try decreasing the dose and then titrating back up, and even that does not work. For years, pharmaceutical companies have been trying to find …

This week, we continue our exclusive short interview series with NuSirt CEO, JC, in which he talks about some of the groundbreaking work his company is doing to increase the effectiveness of metformin.   Steve Freed, Publisher, Diabetes in Control: What actually brought you to taking this compound and combining it …

This week, we’re taking a break from our regularly featured section on avoiding medication mistakes to bring you this exclusive interview series with NuSirt CEO, JC, in which he talks about some of the groundbreaking work his company is doing to increase the effectiveness of metformin. Steve Freed, Publisher, Diabetes …

In this week’s Homerun Slides, Dr. Stanley Schwartz tackles the topic of the best blood glucose levels for a hospital setting. He presents data from several different studies including First DIGAMI and the Portland Diabetic Project, as well as several others in his discussion of this important subject… To download …

Rudy Bilous, MD, FRCP Richard Donnelly, MD, PHD, FRCP, FRACP Symptoms, signs and classification Diabetes is one of the most common causes of peripheral neuropathy, a term that encompasses a heterogeneous group of disorders (Figure 17.1). In population-based surveys, up to one-third of patients with diabetes have evidence of peripheral neuropathy but …

Last night I was in the pharmacy and a 22-year-old man came in with prescriptions for insulin, syringes, glucose meter, test strips and lancets. He had come by motorcycle and while he was waiting for his prescription he never took off his helmet or jacket even though it was 75 …

The once-daily oral tablet is the first in the U.S. to combine the SGLT-2 inhibitor dapagliflozin with the biguanide extended-release (XR) metformin hydrochloride.. The US Food and Drug Administration (FDA) has approved a once-daily combination of dapagliflozin and metformin hydrochloride extended-release (Xigduo XR, AstraZeneca) for the treatment of adults with …

The overall risk of metabolic syndrome decreased with every 100 mg per day increment in magnesium intake…. Previous studies have shown conflicting accounts of how beneficial dietary magnesium intake is in decreasing the risk of metabolic syndrome. The purpose of this meta-analysis was to determine the association between metabolic syndrome …

The addition of a DPP-4 inhibitor decreased HbA1C while not requiring an increase in insulin, and subjects remained weight neutral without experiencing an increase in hypoglycemic events… Currently approved dipeptidyl peptidase-4 (DPP-4) inhibitors include alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin. DPP-4 inhibitors work by enhancing glucose dependent insulin secretion and …

Type 2 diabetes patients were more likely to have lower stress reactivity and impaired stress recovery when compared to healthy subjects… Stress-related factors are thought to play a role in the development of type 2 diabetes. Such factors have an impact on metabolic, cardiovascular and inflammatory regulation. Previous studies have …