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When Patients’ Symptoms Don’t Fit the Diagnosis, Look Deeper

Aug 4, 2020

When you may suspect LADA (latent autoimmune diabetes in adults), sometimes called diabetes type 1.5….

A young man, 32 years of age, with a history of ADHD and being treated with Adderall, was diagnosed with type 2 diabetes. He had symptoms upon diagnosis — frequent urination, weight loss, and his BMI was 20. He followed a low carb diet, was taking metformin, and exercised; however, his blood glucose and A1C continued to rise to 7.7%. His weight loss was thought to be associated with Adderall. When referred to me, I checked C-Peptide (<1), GAD antibodies (positive), and there were mild ketones. Suspecting LADA, I started him on insulin. After this, his health improved.


Lessons Learned:

  • When patients continue to lose weight and blood glucose levels go up despite excellent self-management, suspect LADA, look further, and refer to an endocrinologist.
  • Don’t be afraid to start insulin. It may be the right treatment the patient needs.


Rekha B. Kumar, M.D., M.S.
Assistant Professor of Medicine
Weill Cornell Medical College
Department of Endocrinology, Diabetes, and Metabolism
Comprehensive Weight Control Program
New York, NY


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MODY (maturity-onset diabetes of the young) and LADA (latent autoimmune diabetes in adults) can be difficult to diagnose, and are often misdiagnosed.  See more about MODY/LADA in our condition center.