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Vitamin D Does Not Regulate Blood Sugar in Type 2 Diabetes

Aug 21, 2015

Patients who are diagnosed or are at risk of developing diabetes should not take vitamin D as an alternative to treat the disease….

Low vitamin D has been associated with impaired glycemic control in patients with type 2 diabetes. A study that was done by Diabetes Care demonstrates otherwise.


A double blind, placebo-controlled trial was conducted to evaluate the effect of vitamin D supplementation on glycemic control in patients with type 2 diabetes. There were 275 non-insulin experienced adult patients with type 2 diabetes who were randomly receiving either vitamin D3 (50,000 IU/month) or placebo for 6 months. Linear regression analysis was used to assess changes in HbA1c.

The researchers found out that a mean baseline serum 25-hydroxyvitamin D [25(OH)D] increased from 60.6 ± 23.3 to 101.4 ± 27.6 nmol/L and 59.1 ± 23.2 to 59.8 ± 23.2 nmol/L in the vitamin D and placebo group respectively; both groups had an HbA1c mean baseline of 6.8 ± 0.5% (51 ± 6 mmol/mol).

After 6 months, there were no effects observed on HbA1c (P = 0.42), HOMA of insulin resistance, fasting insulin, glucose and no dissimilarity in patients with a serum 25(OH)D 7% (53 mmol/mol).

“In a well-controlled group of patients with type 2 diabetes, intermittent high-dose vitamin D supplementation did not improve glycemic control,” the researchers wrote.

Practice Pearls:

  • Vitamin D should not be used for diabetes treatment.
  • The study showed that high doses of vitamin D did not improve glycemic control.
  • Vitamin D does not prevent patients from being diagnosed with diabetes.

Krul-Poel, Yvonne H.m., Sanne Westra, Edwin Ten Boekel, Marieke M. Ter Wee, Natasja M. Van Schoor, Hans Van Wijland, Frank Stam, Paul T.a.m. Lips, and Suat Simsek. “Effect of Vitamin D Supplementation on Glycemic Control in Patients With Type 2 Diabetes (SUNNY Trial): A Randomized Placebo-Controlled Trial.” Diabetes Care Dia Care (2015): 1420-426.