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The VERTIS CV Study – SGLT-2 Inhibitors’ Cardiovascular and Renal Outcomes in T2D

Oct 20, 2020
Editor: David L. Joffe, BSPharm, CDE, FACA

Author: Tarshay Boyd, PharmD. Candidate, LECOM School of Pharmacy

This article is part of a live interview about VERTIS CV with Dr. Engel, Associate Vice President, Cardiometabolic and Women's Health, Merck Research Laboratories.  

Cardiovascular events and renal disease in type 2 diabetes are an area of focus seen in studies across the world, including studies of heart failure, stroke, myocardial infarction, and renal disease progression.   

Sodium-glucose cotransporter 2 (SGLT-2) inhibitors play a critical role in managing type 2 diabetes and its complications.   The purpose of the VERTIS CV study was to evaluate the cardiovascular effects of ertugliflozin, an SGLT-2 inhibitor.  Other studies have assessed SGLT-2 inhibitors' effects on cardiovascular and kidney outcomes, showing significant hospitalization benefits for heart failure and renal disease progression.  DAPA-CKD showed that dapagliflozin reduced the risk of kidney disease progression and death in patients with chronic kidney disease with or without type 2 diabetes....

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