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Tag Archives: TrialNet

Can Weight Loss Delay Type 1 Diabetes? What the Pre-Symptomatic Data Really Show

Healthy food, exercise shoes, glucose meter, scale, and pancreas illustration representing weight and type 1 diabetes prevention research.

Efforts to prevent or delay type 1 diabetes have traditionally focused on the autoimmune attack that destroys insulin-producing beta cells. However, emerging research suggests metabolic stress may also influence how quickly vulnerable people progress to clinical disease. A 2026 TrialNet analysis found that autoantibody-positive people with overweight or obesity who …

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The Return of C-Peptide: Why This Old Biomarker Is Finding New Clinical Uses

Healthcare professional reviewing C-peptide test results with a pancreatic model, blood sample, and glucose monitoring equipment representing beta-cell function assessment in diabetes care.

For many years, C-peptide testing was viewed as a simple tool to distinguish type 1 diabetes from type 2 diabetes. However, the story has changed. As researchers gain a better understanding of pancreatic beta-cell function, C-peptide testing in diabetes has become much more valuable than a diagnostic aid alone. Today, …

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The Future of Type 1 Screening: Will Genetics Replace Autoantibodies?

Pediatric genetic screening for type 1 diabetes showing a DNA helix, blood sample, and clinical risk assessment used for early detection of disease risk.

Population-based screening for type 1 diabetes is entering a new era. While autoantibody testing remains the gold standard for identifying individuals at high risk, researchers are increasingly investigating whether type 1 diabetes genetic screening could identify susceptible people even earlier. Advances in genomic science now make it possible to estimate …

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