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Study Links Obesity to Protein in Infant Formula

May 22, 2007

The results of the EU Childhood Obesity Program indicate that low-protein content in infant formula may have metabolic, endocrinal and developmental benefits for babies – which may also have an impact on obesity at a later age. Subject to further follow-up, the findings add weight to the idea that a tendency towards obesity is set in earliest childhood. They come shortly after another study indicated that tendency towards obesity could be genetic.

Professor Berthold Koletzko, project co-coordinator from the University of Munich, Germany, said the results "emphasize the importance of promotion of and support for breastfeeding, together with the development of the right composition of infant formula,  and support for the choice of appropriate complementary food."


The study involved 990 infants and ran from October 2002 to July 2006, when the youngest participants reached the age of two.

The researchers hypothesized the primary hypothesis that one possible causal factor for the difference in long-term obesity risk between breast and formula-fed infants is the much lower protein content of breast milk compared to infant formula.

The infants were randomized to receive either a low-protein formula (1.8g/100kcal, then 2.25g/100kg in follow on formulas) or a high protein formula (3g/100kcal, then 4.5g/100kcal).

The intervention lasted for 12 months from birth, and the infants were followed until they reached the age of two. A group of breast-fed children was also followed.

In addition to a body growth rate similar to that of breast-fed babies, those in the low protein group were seen to have metabolic and endocrinal benefits too.

It is emphasized that the low protein content in the formula is considered safe and is in accordance with the formula composition authorized by the EU. No untoward effects were seen during the study.

The program is part of the Early Nutrition Programming Project (EARNEST), an EU-funded project to investigate the link between nutrition in earliest childhood and health outcomes later in life.

The results were presented at the pre-congress EARNEST satellite conference of the 15th European Congress on Obesity in Budapest by Prof Koletzko.

A spokesperson told NutraIngredients.com it is expected that the study will be published, but it is not yet known when and in which journal. However these results are not the end of the story.

"These first results of the EU Childhood Obesity Program contribute to the growing body of scientific evidence that early nutrition can exert important long term ‘programming’ effects on early development and later health," said Prof Koletzko.

Further follow up of the children is planned under the aegis of EARNEST, to investigate whether the observed effects at age two are associated with a lower risk of obesity at a later age. 
The study will be published, but it is not yet known when and in which journal.