Gastroenterology

Device implantation could be the future in T2DM and weight loss… Weight gain is often a side effect of several different oral antidiabetic drugs (OADs), such as sulfonylureas and thiazolidinedion, along with insulin. Lifestyle modification and weight loss is always recommended in T2DM, but we all know it takes great …

Researchers compared glucose and hormonal responses to a liquid meal test in 20 obese participants with T2 who underwent RYGB or nonsurgical intensive lifestyle modification… Rapid glycemic improvements following Roux-en-Y gastric bypass (RYGB) are frequently attributed to the enhanced GLP-1 response, but causality remains unclear. To determine the role of …

Rudy Bilous, MD, FRCP Richard Donnelly, MD, PHD, FRCP, FRACP Disordered gastrointestinal motor function occurs in both type 1 and type 2 diabetes and can result in symptoms of nausea, vomiting, diarrhea or constipation, malnutrition, poor glycemic control and delayed absorption of orally administered drugs (Figure 23.1). Gustatory sweating, typically affecting the …

  Gastric bypass surgery shows better outcomes for long-term weight loss, controlling type 2 diabetes, hypertension, and cholesterol level…. Puzziferri and colleagues conducted a clinical review of 29 studies (7,971 patients) looking at outcomes of gastric bypass, gastric band or sleeve gastrectomy on patients with BMI ≥35 at 1 year …

According to research done in the SLIMM-T2D randomized trial, gastric bypass surgery may have additional benefits for patients with diabetes and obesity…. 

In a phase 2 trial, patients with diabetic gastroparesis displayed increased gastric emptying and improvement in vomiting after treatment with relamorelin-131…. 

Possible circumvention for anti-nausea drug, metoclopramide, shows promise….  

Differing responses to GLP-1 post-surgery show different rates of metabolic improvement…. 

‘Reprogrammed’ glucose uptake in the small intestine may explain why gastric bypass surgery can sometimes result in the early resolution of type 2 diabetes…. 

Researchers looked at the change in hormones and amino acid levels following gastric bypass surgery….