Scientists Working On A New Insulin Pill

Insulin injections may soon be a thing of the past. A British company has developed a form of the protein that can be taken orally. Scientists at Diabetology, a small research and development company that has spent may years trying to develop oral insulin, believe that it will better control of symptoms. The company has successfully enclosed the insulin in a capsule that prevents it from being digested by stomach acids, and carries it intact into the small intestine. Once the capsule has reached the small intestine, it is dissolved and releases a mixture of insulin and other materials that enhance the absorption of the insulin through the intestinal wall. Thereafter, the insulin is transported to the liver, where it creates a store that can be drawn on by the body.

The researchers say that the mechanism by which the capsule carries insulin into the body approximates the behavior of the pancreas, the source of insulin in healthy people that releases it as it is needed. Diabetology has already carried out a small trial of 16 patients with type 2 diabetes, the commoner type that usually develops in middle age, led by Cardiff University Professor David Owens. Dr Steve Luzio, another researcher at the university, presented the results of the trial at the American Diabetes Association meeting in Chicago. He announced that the oral dose taken twice daily before breakfast and before dinner, controlled glucose levels successfully in the patients treated. Glen Travers, the Executive Chairman of Diabetology, hopes that the product will enable better control of the disease to be achieved, without the increased risk of heart attack that has been linked to the widely used diabetes drug rosiglitazone.

ADA Scientific Sessions June 2007

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DID YOU KNOW:
Yogurt delays onset of diabetes:  Eating yogurt with probiotic bacteria, Lactobacillus acidophilus and Lactobacillus casei, exhibited a significant delaying effect on the progression of diabetes induced by high fructose administration in rats.  “Studies have earlier linked yoghurt with improved lipids but this is the first time a protective benefit has been established for diabetes,” says Dr Anoop Misra, department of diabetes and metabolic diseases, Fortis Group of Hospitals.  The findings have been reported in the latest issue of international journal Nutrition. See this week’s Item #9

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