Scientists Discover a New Treatment for Type 1 Diabetes

Scientists discover that the beta-cells need heparin sulphate to survive.…

The researchers say they have identified a process that causes the destruction of beta cells, which produce insulin in the pancreas. They found that the insulin-producing cells need heparan sulphate, a complex sugar, to survive.

Dr. Charmaine Simeonovic from the John Curtin School of Medical Research in Canberra said in a statement that,  ”We’ve discovered that replacement of heparan sulphate in the beta cells rescues the cells from dying and prevents them from damage caused by oxidation.”

The study identified the depletion of heparan sulphate as a major cause of the death of beta cells. ”We attribute this cell death to loss of the beta cells’ normal defence against damage by oxidation caused by free radicals, or highly chemically reactive atoms, molecules or ions.”

The team also discovered that autoimmune cells damage beta cells by producing heparanase, an enzyme that degrades heparan sulphate in beta cells.

”This has revealed a new understanding of the development of type 1 diabetes and has identified a new therapeutic strategy for preventing progression of the autoimmune disease and associated complications,” Dr Simeonovic said.

The scientists plan to use their discovery to develop new drugs and have already set up a biotechnology company to do so.

The Journal of Clinical Investigation, Dec. 2011.