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Light-mediated vasodilation was first described by R. F. Furchgott, in his nitric oxide research that led to his receipt of a Nobel Prize in 1998. Later studies conducted by other researchers confirm and extend Furchgott’s early work and demonstrate the ability of light or photo energy to influence the localized …

Diabetic Peripheral Neuropathy (DPN: peripheral nerve damage) is a common complication of diabetes. Almost 70% of people with diabetes develop DPN within five years and after five, years the incidence rate increases to almost 100%. DPN most often begins as a tingling feeling and insidiously progresses to loss of sensation …

Nitric Oxide (NO) offers pain relief in a number of ways. In fact, NO is the mediator of the analgesic effect of opioids such as morphine. In this article we describe how NO affects pain responses and, in particular, certain pain responses in people with diabetes. Thomas Burke, Ph.D. Nitric …

Nitric Oxide (NO) and its interrelationship with essential growth factors is critically involved in the entire continuum of events associated with wound repair, including cell division, maturation, neovascularization, and collagen synthesis including proper cross-linking of collagen fibers.     Thomas Burke, Ph.D. Nitric Oxide (NO) and its interrelationship with essential growth …

Diabetic patients are particularly at risk for damage to sensory and motor nerves in the feet or to dysfunction of the autonomic nervous system that innervates internal organs, for example, the intestine. The clinical diagnosis of the latter condition is gastroparesis. NO is an important signaling molecule conveying information from …

NO initiates and maintains vasodilation through a cascade of biological events that culminate in the relaxation of smooth muscle cells that line arteries, veins, lymphatics. While somewhat complex, the sequence of biological events that are triggered by NO is described below:  Thomas Burke, Ph.D.   NO initiates and maintains vasodilation through …

To understand NO metabolism in diabetic patients we must first discuss the normal process of NO formation. NO is a gas that is also a short-lived, unstable free radical and, within seconds of production, must become stabilized. To do so, it reacts with one or more elements or biologic compounds, as …

Nitric Oxide Synthase (NOS) is the enzyme that generates NO from L-arginine as described in Part 1 of this series. However, the enzyme exists in three different forms called isoforms. Each isoform synthesizes NO but does so under different conditions. Often all three isoforms will be found in the same …

This is the first in a series of articles that relate specifically to nitric oxide (NO), a free radical gas that is a powerful regulator of circulation (It is an endogenous vasodilator.) and a neurotransmitter (It helps in the processing of nerve signals as they cross synapses.). L-arginine, one of …

Diabetes in Control is the first to present the Solo product information to the diabetes community.   The FDA approved the Solo MicroPump for sale in the US on July 28th, The Solo MicroPump will be the smallest, lightest, most discreet full-featured insulin pump in the market. In addition, it will offer …