Resources

In this week's Homerun Slides, the general concept of insulin pump therapy and CGM patterns.

Glucose transport: Activation of the insulin signal transduction system in insulin target tissues stimulates glucose transport via a mechanism that involves translocation of a large intracellular pool of glucose transporters (associated with low-density microsomes) to the plasma membrane and their subsequent activation after insertion into the cell membrane.

Reducing HbA1c may be new goal of therapy to prevent coronary artery disease and other subtypes.

Vitamin D shows potential to lower HbA1c, FPG, insulin resistance, and 2-hour post-prandial glucose levels.

Birth weight and maternal glycemia are favorably influenced by dietary changes.

Unsuccessful diabetes management found to lead to more distress, worse patient outcomes.

Sedentary lifestyle, unhealthy eating increasing risk of developing cardiometabolic diseases.

By Sheri R. Colberg, PhD, FACSMJ
It’s possible to gain weight from treating too many bouts of hypoglycemia. I addressed this topic over a decade ago, but it remains relevant and worth revisiting, along with addressing some new insights on weight gain in general with insulin use.

Should we lower the A1c to 5.7 for the diagnosis for diabetes and remove prediabetes as a diagnosis, so that we can treat pharmaceutically? Follow the link to share your opinion.

Your patient has been systematically titrating his basal insulin dose for the last 6 months. His daily dose is NPH .90 U/kg/day. Despite his good efforts, you decide it would be prudent to add a prandial insulin dose to his treatment regimen. Which of the following scenarios might lead you to this conclusion?

A. A1C=7.4%, FPG less than 130 mg/dl, PPG greater than 180 mg/dl
B. A1C=7.0%, FPG less than 130 mg/dl, PPG less than 180 mg/dl
C. A1C=7.0%, FPG less than 120mg/dl, PPG less than 160mg/dl
D. A1C=6.8%, FPG less than 120 mg/dl, PPG less than 160 mg/dl

Follow the link for the answer.