Clinical Presentations

In this week's Homerun Slides, the general concept of insulin pump therapy and CGM patterns.

In this week's Homerun Slides, insulin initiation and a comparison of pharmacokinetic and pharmacodynamic insulins.

Cellular mechanisms of insulin resistance: The cellular events via which insulin initiates its stimulatory effect on glucose metabolism start with binding of the hormone to specific receptors that are present on the cell surface of all insulin target tissues. After insulin has bound to and activated its receptor, “second messengers” are generated and these second messengers activate a cascade of phosphorylation-dephosphorylation reactions that result in stimulation of intracellular glucose metabolism. The first step in glucose utilization involves activation of the glucose transport system, leading to glucose influx into insulin target tissues, primarily muscle. The free glucose, which has entered the cell, subsequently is metabolized by a series of enzymatic steps that are under the control of insulin. Of these, the most important are glucose phosphorylation (catalyzed by hexokinase), glycogen synthase (which controls glycogen synthesis), and phosphofructokinase (PFK) and PDH (which regulate glycolysis and glucose oxidation, respectively).

In this week's Homerun Slides, understanding the disorder of type 1 diabetes and a summary of glycemic recommendations.

In this week's conclusion of this series of Homerun Slides, patient care and triage reminders, and other knowledge-based computerized patient record information.

In this week's Homerun Slides, finding the solution to ineffective disease management.

In this week's Homerun Slides, a look at various principles of disease management.

In this week's Homerun Slides, the benefits of health and disease management programs, which can integrate evidence-based best practices into patient care.

In this week's Homerun Slides, asking the question of how to translate knowledge and implications of pathophysiology, progression, and diabetes complications to the prevention, early diagnosis and optimal treatment of diabetes and its complications.

In this week's Homerun Slides, the natural history and progressive behavior of type 2 diabetes.