February 6, 2021 : Issue #1104

TOP STORIES — Diabetes News and Research

Is It Possible to Train Low-Carb and Compete High-Carb?
By Sheri Colberg, PhD

Empagliflozin Benefit in Heart Failure, With or Without Diabetes

Diabetes in Your Pet May Increase Your Risk

Have you ever heard of a fast fat metabolizer? Typically, people who eat a low carb diet do not have as much glucose in their bodies as carb consumers, and so they more often have to rely on the breakdown of fats to supply energy for activities. Because of this ability to metabolize fat, many athletes believe that Carb Loading has a big impact on performance, especially if it is an endurance exercise.

This week, Dr. Sheri Colberg takes a look at this strategy for euglycemic as well as hyperglycemic patients, and shares her research on carb loading, exercise and diabetes.

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We can make a difference!

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Dave Joffe

Editor-in-chief

By Sheri Colberg, PhD

In the past, most elite athletes attempted to improve performance through strategies to achieve “high CHO availability,” meaning building up adequate pre-exercise glycogen levels and carbohydrate intake during the competition to meet fuel needs, but more recently many have aimed instead for a strategy called “low CHO availability.”

Studies of empagliflozin and dapagliflozin have shown to reduce cardiovascular risk, indicating a class effect for heart failure patients.

A recent cohort study offers more insight into whether cat and dog owners and their pets share a risk of acquiring type 2 diabetes. 

According to findings from a small, retrospective study, men with excess weight or type 2 diabetes can reap more pronounced metabolic benefits from exercise when training is performed in the afternoon vs. morning.

In the study, 32 men with metabolic diseases, including diabetes and obesity, began a 12-week training program. They performed aerobic and resistance exercise training in the morning between 8-10 a.m. (20) or 3-6 p.m. (12), 3 days a week. Researchers found that, compared with participants who trained in the morning, participants who trained in the afternoon experienced more significant beneficial effects of exercise training on peripheral insulin sensitivity, insulin-mediated suppression of adipose tissue lipolysis, fasting plasma glucose levels, exercise performance, and fat mass.” Exercise training in the afternoon also tended to elicit more significant effects on basal hepatic glucose output,” the researchers wrote.

The more significant improvement in peripheral insulin-stimulated glucose disposal observed upon exercise training in the afternoon could primarily be attributed to increased insulin-stimulated glucose oxidation and was paralleled by more significant improvements in fasting plasma glucose levels and exercise performance, the researchers wrote. “Also, a superior decline of fat mass was found upon exercise training in the afternoon compared to morning exercise training. Together, these data provide evidence in humans that the timing of exercise may amplify the beneficial health effects of exercise training.” Physiological Reports Volume 8, Issue 24 January 2021

Diabetes in Control gratefully acknowledges the assistance of the following pharmacy doctoral candidates in the preparation of this week’s newsletters:

Abdullah Al-Ajmi, PharmD Candidate, Skaggs School of Pharmacy and Pharmaceutical Sciences

Adrian Gavre, PharmD Candidate, Philadelphia College of Osteopathic Medicine   

Kassey  James, Pharm.D. Candidate, LECOM School of Pharmacy

Marianis Barreto Quintana, PharmD. Candidate, LECOM School of Pharmacy

Nour Salhab, Pharm.D. Candidate, USF College of Pharmacy

Your Friends in Diabetes Care
Steve and Dave

Diabetes In Control
www.diabetesincontrol.com