June 7, 2016 : DCMS #296

DISASTERS AVERTED — Near Miss Case Studies

 Where There’s One Autoimmune Disorder, There May Be Another

EXCLUSIVE INTERVIEW — Candid Video Interviews with Top Practitioners

Eran Bashan Part 7,  Factoring in Nutrition

HOMERUN SLIDES — Great Clinical Presentation Highlights

Diagnosing Diabetes Mellitus in Adults Part 7

CLINICAL GEMS — The Best from Diabetes Texts

International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #27: Insulin Gene Expression and Biosynthesis Part 3 of 6

MOST POPULAR ARTICLES OF THE MONTH

#1 AACE/ACE Position Statement On SGLT-2 Inhibitors and DKA Risk
#2 What is the Actual Cost of Insulin for Your Patients?
#3 Can a Low-Calorie Diet Reverse Diabetes?

23andMe:  I am sure you have seen the commercials on TV. This is a genetic test that you can get done to learn your ancestry: you simply spit into a tube, mail it away, and presto change-o, all the years of thinking you were from Italy can be erased in a moment. This is a basic example of how our knowledge of the human genome and all the variants and mutations can be used to treat many diseases. This week our Homerun Slides look at how we can identify the variant of diabetes with these types of tests, and maybe customize our therapies.

Your partner in diabetes care,
Dave Joffe
Editor-in-chief

Male, 32 years of age, type 1 diabetes, was following gluten free diet of his own choice. Was never diagnosed, just “feels better” when he doesn’t eat gluten. Has lab tests that were negative for celiac in the past. Came to see me for follow up diabetes education. Noted weight loss of 5 pounds in one week. Glucose levels were not elevated, in fact for the most part in target range.

In the conclusion of this Exclusive Interview, DIC publisher Steve Freed asks how nutrition is integrated into the d-Nav insulin management program.

In this week’s Homerun Slides, the cost of the current diabetes classification.

Dysregulation of the insulin gene: There is convincing evidence that abnormalities in insulin gene sequence or function play a role in pancreatic beta-cell dysfunction in type 2 diabetes. Abnormalities in the insulin gene structure consist of rare control region mutations, while insulin gene expression appears to be reduced by metabolic conditions associated with the diabetic state.

A year after the FDA warning, a strong response to the question: are SGLT-2 inhibitors safe?

For patients in the U.S., the price of this lifesaving treatment has risen dramatically.

In study, 40 percent of adults with type 2 diabetes achieved a fasting glucose level of less than 126mg/dL.(7mmol/L) after eight weeks on a very low-calorie diet.