Mouth Spray with Natural Chemical Induces Satiety

The study with mice used a simple mouth spray containing peptide YY, a naturally occurring gut hormone released after eating…. 

The results suggest that taking it via this route half an hour before food could prove a safer way to help with weight loss, the lead researcher said.

Sergei Zolotukhin, PhD, an associate professor of cellular and molecular therapy at the University of Florida’s College of Medicine, continued, "When mice were treated with a solution of this peptide using a simple spray, with one puff they will consume less food and they will start losing weight."

"The implications are very simple: if you put peptide YY in a spray or gum and you take it half an hour before dinner, you will feel full faster and consume less food." "It could be just a 5 or 10% difference, but it is enough to stimulate weight loss."

The researchers note that other oral weight-loss sprays are already on the market, but they say that these are not "backed by medical science." While many show no evidence of harm, nor do many show evidence of benefit, and some are unsafe and illegal.

The Journal of Neuroscience, Dec. 2013