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Metformin: A Potential Anti-Cancer Agent

Mar 20, 2021
 
Editor: David L. Joffe, BSPharm, CDE, FACA

Author: Shana Indawala, PharmD Candidate, University of South Florida Health, Taneja College of Pharmacy

Use of metformin was associated with a 16% reduced risk for overall mortality in patients with type 2 diabetes and pancreatic cancer.  

In addition to treating patients with type 2 diabetes, recent research has shown that metformin expresses an anti-cancer effect through the rapamycin-signal pathway and the ataxia telangiectasia mutated/liver kinase B1/adenosine 5'-monophosphate-acted protein kinase axis. A relationship between cancer of the pancreas and type 2 diabetes exists, with a significantly higher incidence of cancer and cancer-related mortality in patients with diabetes. Previous epidemiologic research and meta-analysis have showcased the relationship between metformin use and pancreatic cancer risk; however, the relationship is still unclear....

 

 

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